Endometrial Decidualization: The Primary Driver of Pregnancy Health.

International Journal of Molecular Sciences
Shu-Wing NgErrol R Norwitz

Abstract

Interventions to prevent pregnancy complications have been largely unsuccessful. We suggest this is because the foundation for a healthy pregnancy is laid prior to the establishment of the pregnancy at the time of endometrial decidualization. Humans are one of only a few mammalian viviparous species in which decidualization begins during the latter half of each menstrual cycle and is therefore independent of the conceptus. Failure to adequately prepare (decidualize) the endometrium hormonally, biochemically, and immunologically in anticipation of the approaching blastocyst-including the downregulation of genes involved in the pro- inflammatory response and resisting tissue invasion along with the increased expression of genes that promote angiogenesis, foster immune tolerance, and facilitate tissue invasion-leads to abnormal implantation/placentation and ultimately to adverse pregnancy outcome. We hypothesize, therefore, that the primary driver of pregnancy health is the quality of the soil, not the seed.

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Citations

Jan 23, 2021·Journal of Clinical Medicine·Hiromi MurataHidetaka Okada
Mar 19, 2021·The Cochrane Database of Systematic Reviews·Bich Ngoc BuiFrank J Broekmans
Jun 7, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Saratchandra Singh Khumukcham, Bramanandam Manavathi
Jul 4, 2021·Tissue & Cell·Carlo TicconiAsgerally Fazleabas
Jul 25, 2021·International Journal of Molecular Sciences·Jia-Peng HeJi-Long Liu
Jul 15, 2021·The Journal of Clinical Endocrinology and Metabolism·Jie YuRobert N Taylor
Nov 18, 2021·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Ahmed M MagedEman A Hussein

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Methods Mentioned

BETA
contraception
histone acetylation
ChIP-Seq
RNA-Seq

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