PMID: 7370682Mar 22, 1980Paper

Endometrial disease after treatment with oestrogens and progestogens in the climacteric

British Medical Journal
M E PatersonJ W Studd

Abstract

A prospective study of 745 women receiving different regimens of hormone treatment for the climacteric for a total of 21 736 months was performed. There was a lower incidence of endometrial hyperplasia in biopsy specimens in the women receiving cyclical low-dose oestrogen by mouth than in those receiving cyclical high-dose oestrogen by mouth. The incidence of abnormalities in the women receiving sequential oestrogen and progestogen was lower than in either of these two groups. Among the women receiving subcutaneous oestrogen implants the incidence was higher still, but over half of the abnormal specimens were from women who had not taken their progestogen. The incidence of hyperplasia fell with longer courses of progestogen, and no hyperplasia was found in patients taking progestogen for over 10 days each month. The incidence of adenomatous and atypical hyperplasia is significantly reduced by a progestogen when taken for 10 or more days monthly. The absence of vaginal bleeding or of a regular bleeding response does not guarantee histologically normal endometrium in patients taking oestrogens without progestogen.

References

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Citations

Sep 1, 1995·American Journal of Obstetrics and Gynecology·W Thompson
Jan 1, 1983·The International Journal of Biochemistry·E UtaakerE Segadal
Dec 16, 1997·American Journal of Obstetrics and Gynecology·R D Gambrell
Aug 7, 1998·Contraception·D L Moyer, J C Felix
Aug 29, 2000·Obstetrics and Gynecology·R J KurmanD L Moyer
Dec 17, 1994·Lancet·M Padwick
Jan 1, 1993·Baillière's Clinical Endocrinology and Metabolism·T M Mack
Jan 1, 1993·Baillière's Clinical Endocrinology and Metabolism·J W Studd, R N Smith
Sep 21, 2006·Journal of the National Cancer Institute·Timothy R RebbeckBrian L Strom
Dec 16, 2000·BJOG : an International Journal of Obstetrics and Gynaecology·D W SturdeeA J Bragg
Sep 19, 1981·British Medical Journal·J O Drife
Oct 28, 1989·BMJ : British Medical Journal·P Wardle, R Fox
Feb 17, 1990·BMJ : British Medical Journal·K F GangarM P Cust
Dec 5, 1992·BMJ : British Medical Journal·H S Jacobs, F E Loeffler
May 29, 2001·Journal of Clinical Pathology·K M Feeley, M Wells
Aug 1, 1992·Postgraduate Medical Journal·K T Khaw
Nov 1, 1995·Environmental Health Perspectives·B S Hulka, L A Brinton
Jul 23, 1983·British Medical Journal
Oct 19, 2007·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·John Studd
May 9, 2013·Climacteric : the Journal of the International Menopause Society·D W Sturdee
Sep 1, 2011·Climacteric : the Journal of the International Menopause Society·J W Studd
Jan 1, 1990·American Journal of Obstetrics and Gynecology·G L RubinS Becker
Jun 1, 1992·American Journal of Obstetrics and Gynecology·R A Lobo
Mar 1, 1985·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·L C Handy
Nov 28, 2008·Best Practice & Research. Clinical Obstetrics & Gynaecology·Jo Marsden, David Sturdee
Jan 1, 1990·Critical Reviews in Oncology/hematology·B Lindahl
Sep 1, 1996·Baillière's Clinical Obstetrics and Gynaecology·M C Rees

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