Endometrial effect of progesterone delivered by vaginal rings in estrogen-treated postmenopausal women

Climacteric : the Journal of the International Menopause Society
G NoéH B Croxatto

Abstract

The type of estrogen and progestin as well as their doses, route and regimens of administration may each affect the benefit-risk profile of postmenopausal hormone therapy. The aim of this study was to evaluate the endometrial effect of progesterone released continuously from a vaginal ring, combined with transdermal estradiol in postmenopausal women. Forty-four postmenopausal women participated in a randomized, double-blind, dose-finding study evaluating two hormonal treatments, combining 50 microg/day of estradiol delivered by transdermal patches and either 0.5-g or 1-g progesterone vaginal rings (PVR) given for 12 weeks. The effect on the endometrium was assessed by histology and the detection of the proliferative marker Ki-67. We also measured the serum concentration of estradiol and progesterone, the tissue concentration of progesterone and the immunolocalization of estradiol and progesterone receptors in the endometrium. Endometrial thickness was increased after both treatments, although endometrial histology appeared atrophic in most biopsies. A circulating dose-response of serum progesterone levels was observed from the first to the 12th week of PVR use. In the high-progesterone-dose group, the scarce presence of Ki-67 a...Continue Reading

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Citations

Dec 13, 2003·Maturitas·René Druckmann
Jun 10, 2016·Climacteric : the Journal of the International Menopause Society·P StuteL Wildt
Mar 17, 2017·Climacteric : the Journal of the International Menopause Society·M L'Hermite
Apr 10, 2018·Climacteric : the Journal of the International Menopause Society·S Mirkin
May 24, 2018·Climacteric : the Journal of the International Menopause Society·R Sitruk-Ware

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