Endometrial expression of selected transcripts in postpartum of primiparous Holstein cows with clinical and subclinical endometritis

Animal Reproduction Science
Howard JohnsonOscar A Peralta

Abstract

Postpartum endometritis compromises milk production and fertility in high-producing dairy cows. Infection of the endometrium induces an inflammatory response with secretion of cytokines that lead to polymorphonuclear cells (PMN) influx and bacterial clearance. Considering that only a portion of cows with endometritis is eligible for clinical diagnosis, there is an increasing effort for developing reliable tools and protocols for diagnosis of subclinical endometritis. Recent reports have indicated that primiparous cows are at greater risk of uterine infection and primiparous cows with subclinical endometritis produce less milk compared to healthy cows. In the present study, gene expression profiles were compared for selected cytokine and hormone endometrial transcripts in the postpartum of primiparous Holstein cows with clinical and subclinical endometritis. Cows were classified as healthy (no signs of clinical endometritis), cows with subclinical endometritis (PMN<5% in the cytological sample) and cows with clinical endometritis (PMN>5%). Although, cows with clinical endometritis had greater (P<0.05) relative amounts of mRNA for the IL1A, IL6, IL17A, TNFα, PGES and PGHS2 genes compared to healthy cows; no significant difference...Continue Reading

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Citations

May 10, 2016·Theriogenology·Pat LonerganDimitrios Rizos
Oct 19, 2016·Animal : an International Journal of Animal Bioscience·V MauffréF Constant
Jul 13, 2016·Scientific Reports·Vanmathy Kasimanickam, John Kastelic
Nov 17, 2019·The Journal of Pharmacology and Experimental Therapeutics·Chao ZhangJinshan Cao
Jan 23, 2021·Animals : an Open Access Journal From MDPI·Dawid TobolskiWojciech Barański
Apr 26, 2021·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Yang DengWei Mao

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