Endometrial expression of steroid receptors in postmenopausal hormone replacement therapy users: relationship to bleeding patterns

The Journal of Family Planning and Reproductive Health Care
Susheel VaniMartha Hickey

Abstract

Mechanisms of menopausal hormone replacement therapy (HRT)-related bleeding, undoubtedly mediated through endometrial steroid receptors, are poorly understood. We aimed to determine the steroid receptor expression in HRT-exposed endometrium in relation to disturbances of bleeding patterns. Prospective observational study in a tertiary referral menopause clinic in Western Australia. Thirty-eight outpatient endometrial biopsies (seven from women not on HRT, 31 from HRT users) were collected from 21 postmenopausal women during and outside bleeding episodes. Eleven women provided multiple biopsies. We performed an immunohistochemical analysis of endometrial glandular, stromal, epithelial, perivascular and endothelial expression of progesterone receptor (PR), glucocorticoid receptor (GR), androgen receptor (AR), estrogen receptors alpha and beta (ERalpha and ERbeta) and studied their relationship to bleeding patterns. In HRT users, during a bleeding episode, there was a trend (non-significant) towards a decrease in PR and an increase in GR in endometrial glandular cells. No differences were observed in AR and ER expression. We have been unable to demonstrate significant differences in steroid receptor expression in endometrium of wo...Continue Reading

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Oct 12, 2014·Human Reproduction Update·D K HapangamaJ N Bulmer
Jul 3, 2009·Biology of Reproduction·Natalie J HannanLois A Salamonsen
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Nov 21, 2018·Language, Speech, and Hearing Services in Schools·Douglas B PetersenTrina D Spencer
Aug 3, 2019·Fertility and Sterility·Stefania SalsanoFrancisco Domínguez

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