Endometrial gene expression analysis at the time of embryo implantation in women with unexplained infertility

Molecular Human Reproduction
Signe AltmäeAnneli Stavreus-Evers

Abstract

Successful embryo implantation depends on the quality of the embryo, as well as on the receptivity of the endometrium. The aim of this study was to investigate the endometrial gene expression profile in women with unexplained infertility in comparison with fertile controls at the time of embryo implantation in order to find potential predictive markers of uterine receptivity and to identify the molecular mechanisms of infertility. High-density oligonucleotide gene arrays, comprising 44 000 gene targets, were used to define the endometrial gene expression profile in infertile (n = 4) and fertile (n = 5) women during the mid-secretory phase (day LH + 7). Microarray results were validated using real-time PCR. Analyses of expression data were carried out using non-parametric methods. Hierarchical clustering and principal component analysis showed a clear distinction in endometrial gene expression between infertile and fertile women. In total we identified 145 significantly (>3-fold change) up-regulated and 115 down-regulated genes in infertile women versus controls. Via Database for Annotation, Visualization and Integrated Discovery functional analysis we detected a substantial number of dysregulated genes in the endometria of infe...Continue Reading

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Jan 8, 2013·Molecular Aspects of Medicine·Shuang ZhangD Randall Armant
Oct 2, 2013·Human Reproduction Update·Signe AltmäeAndres Salumets
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Mar 11, 2010·Current Opinion in Obstetrics & Gynecology·Lusine Aghajanova

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