Endometrial injury for patients with endometriosis and polycystic ovary syndrome undergoing medically assisted reproduction: current data and a protocol

Hormone Molecular Biology and Clinical Investigation
Charalampos SiristatidisAntonis Makrigiannakis

Abstract

We propose a study protocol capable of improving clinical outcomes following medically assisted reproduction (MAR) in infertile women with endometriosis and polycystic ovary syndrome (PCOS). The proposed research derives from the published evidence on the positive impact from endometrial injury (EI) and the beneficial nature of the intervention towards improved implantation rates. We primarily refer to the cluster of events and hypotheses, such as the mechanical cascade, the inflammatory response per se, the events accompanying wound healing, the immune cell recruitment and protein involvement, alterations in gene expression and the neo-angiogenesis theories, which have been previously investigated for this purpose. We are also exploring the possible problems in MAR cycles with negative outcomes in PCOS and endometriosis patients and we are proposing potential mechanisms on how this intervention might work. Our hypothesis states that the EI before the initiation of the MAR cycle can affect clinical pregnancy rates in patients with the aforementioned pathologies.

References

Jan 1, 1980·American Journal of Obstetrics and Gynecology·J DorD M Serr
Jan 24, 2002·Biology of Reproduction·K B C ApparaoBruce A Lessey
Jun 7, 2002·The Journal of Clinical Endocrinology and Metabolism·Christopher W GregoryBruce A Lessey
Jan 10, 2003·The Journal of Clinical Endocrinology and Metabolism·Dilek CermikHugh S Taylor
Apr 8, 2003·The Journal of Clinical Endocrinology and Metabolism·Kotaro KitayaHideo Honjo
Jun 5, 2003·Lancet·Paul HardimanWilliam Atiomo
Jan 13, 2006·Molecular and Cellular Endocrinology·Serdar E BulunJ Julie Kim
Mar 13, 2008·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Alessandro D GenazzaniValerio M Jasonni
Apr 9, 2009·Current Opinion in Obstetrics & Gynecology·Rong Li, Guiqin Hao
May 15, 2009·Fertility and Sterility·Joanne GunbyUNKNOWN IVF Directors Group of the Canadian Fertility and Andrology Society
Feb 23, 2010·Fertility and Sterility·Benjamin AlmogTogas Tulandi
Apr 21, 2011·Human Reproduction·A P FerrarettiUNKNOWN ESHRE working group on Poor Ovarian Response Definition
Feb 3, 2012·Cell and Tissue Research·Julie A W StilleyKathy L Sharpe-Timms
Oct 16, 2012·Reproductive Biomedicine Online·Neelam PotdarLuciano G Nardo
Mar 1, 2013·Seminars in Reproductive Medicine·Bruce A LesseyRobert N Taylor
Mar 29, 2013·Reproductive Sciences·Rakesh K SharmaAshok Agarwal
Jul 12, 2013·Human Reproduction·A P FerrarettiUNKNOWN European IVF-Monitoring (EIM) Consortium for the European Society of Human Reproduction and Embryology (ESHRE)
Jan 3, 2015·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Maria Cândida P BaracatEdmund C Baracat
May 30, 2015·Scientific Reports·Bo XuYu-sheng Liu
Nov 26, 2015·Seminars in Reproductive Medicine·Ayse SeyhanGürkan Uncu
Dec 15, 2015·Fertility and Sterility·Lynn SterlingEllen Greenblatt
Jun 15, 2016·The Cochrane Database of Systematic Reviews·Sarah F LensenCindy Farquhar
Jun 17, 2016·Database : the Journal of Biological Databases and Curation·Àlex BravoLaura I Furlong
Dec 3, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Charalampos SiristatidisNikolaos Papantoniou
Dec 7, 2016·Human Reproduction·Neil P JohnsonUNKNOWN World Endometriosis Society Sao Paulo Consortium
Jan 26, 2017·Reproductive Biology and Endocrinology : RB&E·Mireia González-ComadranMiguel Ángel Checa

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Contributions to Gynecology and Obstetrics
B HedonJ L Viala
Acta Obstetricia Et Gynecologica Scandinavica
J C AureP Kolstad
Current Opinion in Obstetrics & Gynecology
B Ranney
© 2022 Meta ULC. All rights reserved