Endometrial miR-200c is altered during transformation into cancerous states and targets the expression of ZEBs, VEGFA, FLT1, IKKβ, KLF9, and FBLN5.

Reproductive Sciences
Harekrushna PandaNasser Chegini

Abstract

A number of microRNAs (miRNAs), including miR-200 family, are aberrantly expressed in endometriosis and endometrial cancer. Here we assessed the expression and functional aspects of miR-200c in endometrial tissues (N = 52) from normal endometrial biopsies (N = 15), endometrial tissues including those exposed to hormonal therapies (N = 20), and grade I-III endometrial cancer (N = 17). miR-200c expression was elevated in normal endometrial biopsies from mid- and late-luteal phase, and in endometrial tumors as compared to endometrial tissues from peri- and postmenopausal period (P < .05) and its pattern of temporal expression displayed an inverse relationship with the expression of ZEBs. The expression of E-cadherin (CDH1) varied, but expressed at low levels, specifically in endometrial tissues and endometrial tumors. The endometrial expression of ZEBs and CDH1 in patients who were exposed to Depo-Provera and gonadotropin-releasing hormone agonist GnRHa displayed a trend toward lower expression as compared to proliferative phase; however, treatment of Ishikawa cells with 17β-estradiol, progesterone, and medroxy progesterone acetate had modest effects on the expression of miR-200c and ZEBs without affecting CDH1 expression. Gain of...Continue Reading

References

Feb 13, 2001·Molecular Human Reproduction·A E KingR W Kelly
Nov 30, 2005·Nucleic Acids Research·Cindy VandewalleGeert Berx
Apr 6, 2006·Cancer Research·Nicole S SpoelstraJennifer K Richer
Mar 4, 2008·Fertility and Sterility·Murat UlukusAydin Arici
May 20, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Meenakshi SinghJennifer K Richer
May 24, 2008·Gynecologic Oncology·Todd BorenJohnathan M Lancaster
Aug 9, 2008·Molecular Endocrinology·Ankur K NagarajaMartin M Matzuk
Nov 13, 2008·Reproductive Sciences·Robert N TaylorNeil Sidell
Dec 17, 2008·Molecular Endocrinology·E Maria C Ohlsson TeagueLouise M Hull
Feb 7, 2009·Molecular Reproduction and Development·Gabriel Gonzalez, Richard R Behringer
Jun 3, 2009·The Journal of Clinical Investigation·Raghu Kalluri, Robert A Weinberg
Jul 10, 2009·Cell Cycle·Veronica Davalos, Manel Esteller
Sep 30, 2009·PloS One·Derek M DykxhoornJudy Lieberman
Dec 1, 2009·Cell·Jean Paul ThieryM Angela Nieto
Jan 6, 2010·Journal of Oncology·Dawn R CochraneJennifer K Richer
Mar 20, 2010·Journal of Biomedicine & Biotechnology·Nicoletta FilighedduNicola Surico
Apr 20, 2010·American Journal of Obstetrics and Gynecology·David E CohnKimberly E Resnick
May 14, 2010·Biology of Reproduction·Hongling DuHugh S Taylor
Jun 11, 2010·Annual Review of Biochemistry·Marc Robert FabianWitold Filipowicz
Jul 29, 2010·Cancer Research·Derek M Dykxhoorn
Aug 14, 2010·EMBO Reports·Simone Brabletz, Thomas Brabletz
Nov 3, 2010·Gynecologic Oncology·Jeong-Won LeeDuk-Soo Bae
Nov 17, 2010·Proceedings of the National Academy of Sciences of the United States of America·Nora E RenthalCarole R Mendelson
Nov 18, 2010·The Journal of Biological Chemistry·Yuk Cheung ChanChandan K Sen
Dec 1, 2010·Molecular Cancer Research : MCR·Jonathon D RoybalJonathan M Kurie
Dec 3, 2010·The Journal of Pathology·María Ángeles CastillaJosé Palacios
Jan 13, 2011·The EMBO Journal·Simone BrabletzThomas Brabletz
Jan 21, 2011·Nature·Eric M Small, Eric N Olson
Feb 5, 2011·Science·Sergej DjuranovicRachel Green
Feb 22, 2011·Human Reproduction·Luis A RamónAmparo Estellés
Mar 2, 2011·The American Journal of Pathology·Jacqueline A MaybinHilary O D Critchley

❮ Previous
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Citations

Jul 17, 2012·Molecular Endocrinology·Shannon M HawkinsMartin M Matzuk
Jan 7, 2014·PloS One·LaTanya V WilliamsOlga V Volpert
Jun 24, 2014·Cellular & Molecular Immunology·Mallikarjun BidarimathChandrakant Tayade
Feb 10, 2016·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·C N Kent, I K Guttilla Reed
Jun 16, 2015·Frontiers in Nutrition·Rosanna H E Krakowsky, Trygve O Tollefsbol
Feb 24, 2015·Archives of Gynecology and Obstetrics·Argiri SianouEvangelia Kouskouni
Mar 31, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Mei DongFang Hua
Dec 13, 2016·International Journal of Molecular Sciences·Ying PengGong-She Yang
Feb 22, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Hong-Xia ChenXiao-Dong Zhou
Aug 21, 2012·Human Reproduction·Luis A RamónJuan Gilabert-Estellés
Aug 18, 2012·Nature Reviews. Cancer·Heiko Hermeking
Jan 30, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Vishal PatelVishal Nigam
Jul 8, 2020·Cell Medicine·Sandeep SatapathyRoshan Kumar Singh
Apr 13, 2018·Reproductive Sciences·Tsai-Der Chuang, Omid Khorram
Feb 21, 2019·Experimental and Therapeutic Medicine·Jiedong LiangHe Huang
Apr 30, 2020·International Journal of Molecular Sciences·Michał CiebieraArtur Czekierdowski
Jun 8, 2017·International Journal of Molecular Sciences·Pui-Wah Choi, Shu-Wing Ng
Jan 30, 2018·Human Reproduction Update·Matthias W Laschke, Michael D Menger
Sep 12, 2020·Cancers·Iwona SidorkiewiczAdam Krętowski
Dec 5, 2017·Laboratory Investigation; a Journal of Technical Methods and Pathology·Yongmei CaoYingchuan Li
Dec 20, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Fengju SongKexin Chen
Jan 12, 2021·Biochemical Pharmacology·Shilpi SinghSuaib Luqman
Feb 19, 2021·Journal of Gynecology Obstetrics and Human Reproduction·Sema MisirYüksel Aliyazicioglu
Mar 31, 2021·Gynecologic Oncology·Neda RahimianHamed Mirzaei

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Methods Mentioned

BETA
biopsies
hysterectomy
PCR
transfection
Assay
Protein Assay

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