Endometrial miR-543 Is Downregulated During the Implantation Window in Women With Endometriosis-Related Infertility.

Reproductive Sciences
Puyu YangLiying Yan

Abstract

Differentially expressed microRNAs (miRNAs) and their target mRNAs may lead to alterations in normal physiological status of the tissues and initiate pathological processes. The aim of this study was to investigate the expression of the most relevant miRNAs in the eutopic endometrial tissue during the window of implantation in women with endometriosis-related infertility. In the study, 76 infertile women with a regular menstrual cycle were recruited from the Center for Reproductive Medicine, Peking University Third Hospital between January 2014 and June 2016. We performed a combined messenger RNA and miRNA microarray and bioinformatics analysis of eutopic endometrium in 6 women with and without endometriosis-related infertility at the time of implantation window. Quantitative real-time polymerase chain reaction arrays were utilized to examine the expression levels of selected miRNAs (from 35 patients with endometriosis and 35 disease-free individuals at different menstrual stages). Five differentially expressed miRNAs (miR-142-5p, miR-146a-5p, miR-1281, miR-940, and miR-4634) were significantly upregulated, whereas miR-543 was significantly downregulated in the eutopic endometrium during the window of implantation in patients w...Continue Reading

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Citations

Aug 28, 2020·Frontiers in Oncology·Soudeh Ghafouri-FardMohammad Taheri
Jun 17, 2020·Journal of Cellular Physiology·Cong ZhouShiwei Duan
May 27, 2021·Clinical Epigenetics·Alejandra Monserrat Retis-ResendizEdgar Ricardo Vázquez-Martínez
Aug 28, 2021·Journal of Clinical Medicine·Kamila KolanskaEmile Daraï

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