Endometrial safety with a low-dose intrauterine levonorgestrel-releasing system after 3 years of estrogen substitution therapy

Maturitas
Dirk WildemeerschN De Wever

Abstract

To evaluate the pharmacodynamic effects of a novel intrauterine drug delivery system, FibroPlant-levonorgestrel (LNG), on the endometrium in 24 postmenopausal women using estrogen substitution therapy (EST) to suppress climacteric symptoms. A 3-year non-comparative prospective clinical trial. The treatment with the FibroPlant-LNG intrauterine system (IUS), releasing 14 microg of LNG per day, was part of a regimen for estrogen substitution therapy in symptomatic postmenopausal women to prevent endometrial proliferation and bleeding. The majority of women received percutaneous 17 beta estradiol, 1.5 mg daily, or an equivalent dose by patch or orally, on a continuous basis. Menstrual pattern, endometrial histology and ultrasonographic evidence of endometrial suppression, after 3 years of use. The endometrial histology specimen showed profound endometrial suppression with glandular atrophy and stroma decidualization in all women. On transvaginal ultrasound, this corresponds with a thin endometrium (<5 mm) and clinically with a "bleed-free" menstrual pattern or amenorrhoea. The results of this 3-year study in 24 postmenopausal women using EST suggest that the FibroPlant-LNG IUS is effective in causing strong suppression of the endom...Continue Reading

References

Jan 1, 1986·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·S G SilverbergT Luukkainen
Apr 1, 1986·Ultrasound in Medicine & Biology·A C FleischerS S Entman
Jan 1, 1995·American Journal of Obstetrics and Gynecology·T H RaudaskoskiT J Laatikainen
Feb 1, 1995·American Journal of Obstetrics and Gynecology·S P SuhonenP Lähteenmäki
Feb 1, 1997·Acta Obstetricia Et Gynecologica Scandinavica·S SuhonenP Lähteenmäki
Aug 24, 2001·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·D Wildemeersch, E Schacht
Mar 26, 2002·Climacteric : the Journal of the International Menopause Society·F E Riphagen
Jun 1, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Dirk Wildemeersch, E Schacht
Jul 19, 2002·JAMA : the Journal of the American Medical Association·Jacques E RossouwUNKNOWN Writing Group for the Women's Health Initiative Investigators
May 16, 2003·American Journal of Obstetrics and Gynecology·D Wildemeersch, M Dhont
Jun 26, 2003·JAMA : the Journal of the American Medical Association·Christopher I LiJanet R Daling

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