Endometrial Scratch Injury Induces Higher Pregnancy Rate for Women With Unexplained Infertility Undergoing IUI With Ovarian Stimulation: A Randomized Controlled Trial

Reproductive Sciences
Ahmed M MagedNoura Elnassery

Abstract

To explore the impact of endometrial scratch injury (ESI) on intrauterine insemination (IUI) success. One hundred and fifty four infertile women received 100 mg of oral clomiphene citrate for 5 days starting on day 3 of the menstrual cycle. Patients were randomized to 2 equal groups: Group C received IUI without ESI and group S had ESI. Successful pregnancy was confirmed by ultrasound. 13, 21, and 10 women got pregnant after the first, second, and third IUI trials, respectively, with 28.6% cumulative pregnancy rate (PR). The cumulative PR was significantly higher in group S (39%) compared to group C (18.2%). The PR in group S was significantly higher compared to that in group C at the second and third trials. The PR was significantly higher in group S at the second trial compared to that reported in the same group at the first trial but nonsignificantly higher compared to that reported during the third trial, while in group C, the difference was nonsignificant. Eight pregnant women had first trimester abortion with 18.2% total abortion rate with nonsignificant difference between studied groups. The ESI significantly improves the outcome of IUI in women with unexplained infertility especially when conducted 1 month prior to IUI.

Associated Clinical Trials

Aug 11, 2016·khalid mohammed salama, khalid mohammed salama

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Citations

Jun 15, 2016·The Cochrane Database of Systematic Reviews·Sarah F LensenCindy Farquhar
Jan 24, 2019·The New England Journal of Medicine·Sarah LensenCynthia Farquhar
Nov 6, 2018·Human Reproduction Update·Chen Sar-Shalom NahshonMartha Dirnfeld
Feb 6, 2016·American Journal of Reproductive Immunology : AJRI·Arsène MekinianMarie Bornes
Mar 19, 2021·The Cochrane Database of Systematic Reviews·Bich Ngoc BuiFrank J Broekmans
Oct 2, 2017·Journal of Gynecology Obstetrics and Human Reproduction·G C SenocakB Borekci
Nov 18, 2021·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Ahmed M MagedEman A Hussein

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Methods Mentioned

BETA
biopsy
scraping

Software Mentioned

SPSS

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