Endometrial Stromal Sarcomas: A Revision of Their Potential as Targets for Immunotherapy

Vaccines
Sandra Tuyaerts, Frédéric Amant

Abstract

Endometrial stromal sarcomas are a subtype of uterine sarcomas that are characterized by recurrent chromosomal translocations, resulting in the expression of tumor-specific fusion proteins that contribute to their tumorigenicity. These characteristics make the translocation breakpoints promising targets for immunotherapeutic approaches. In this review, we first describe the current knowledge about the classification of endometrial stromal sarcomas, and their molecular and genetic characteristics. Next, we summarize the available data on the use of translocation breakpoints as immunotherapeutic targets. Finally, we propose a roadmap to evaluate the feasibility of immunologic targeting of the endometrial stromal sarcoma-specific translocations in patients with recurrent disease.

References

May 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·J I KoontzJ Sklar
Jan 14, 2005·Journal of Translational Medicine·Satoshi KawaguchiToshihiko Yamashita
Apr 20, 2005·Cancer Immunology, Immunotherapy : CII·David A RodebergEsteban Celis
Aug 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Crystal L MackallLee J Helman
Jul 9, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christopher A KlebanoffNicholas P Restifo
Sep 10, 2011·Drugs·Katayoun Rezvani, Hugues de Lavallade
Jan 10, 2012·Proceedings of the National Academy of Sciences of the United States of America·Cheng-Han LeeJonathan A Fletcher
Aug 11, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christopher H EvansJames W Wells
Aug 21, 2013·International Journal of Cancer. Journal International Du Cancer·Barbara DewaeleMaria Debiec-Rychter
Mar 25, 2014·Cancer Immunology, Immunotherapy : CII·Anke VanderstraetenFrederic Amant
Jul 18, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Frédéric AmantBeatrice Seddon
Oct 10, 2014·Advances in Anatomic Pathology·Christopher M J Conklin, Teri A Longacre
Sep 4, 2016·Taiwanese Journal of Obstetrics & Gynecology·Huann-Cheng HorngUNKNOWN Taiwan Association of Gynecology Systematic Review Group
Sep 16, 2016·The American Journal of Surgical Pathology·Lien N HoangSarah Chiang
Feb 1, 2017·Journal of Clinical Pathology·Benjamin Nathanael LokeKenneth Tou En Chang
Mar 10, 2017·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Shintaro Sugita, Tadashi Hasegawa
Mar 24, 2017·Gynecologic Oncology Reports·Allison J AllenTanja Pejovic
Jun 2, 2017·JCI Insight·Joanna PrzybylMaria Debiec-Rychter
Jun 10, 2017·Gynecologic Oncology·Brandon-Luke L SeagleShohreh Shahabi
Jun 18, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sarah ChiangRobert A Soslow
Dec 2, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Natasha LewisSarah Chiang
Dec 5, 2017·The American Journal of Surgical Pathology·Adrián Mariño-EnriquezJonathan A Fletcher
Mar 2, 2018·World Journal of Gastroenterology : WJG·Shinpei OginoEigo Otsuji
May 31, 2018·Current Opinion in Oncology·Justine Gantzer, Isabelle Ray-Coquard

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
hysterectomy

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.