Endometrial structural and inflammatory changes with exogenous progestogens

Trends in Endocrinology and Metabolism : TEM
Martha Hickey, Lois A Salamonsen

Abstract

Safe and effective contraception is an international public health priority. The long-acting progestogen-only contraceptives are used by over 20 million women worldwide but their main drawback is abnormal uterine bleeding. Such bleeding arises owing to structural and inflammatory changes which compromise endometrial microvascular and epithelial integrity. The molecular and structural changes that lead to the vessel and surface epithelial fragility, and hence the side effect of abnormal uterine bleeding commonly seen with exogenous progestogen use, might be lessened by short-term treatments shown to shorten bleeding episodes.

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Citations

Nov 2, 2012·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Mohamed LabanAhlam Ibrahim
Mar 16, 2011·Annals of the New York Academy of Sciences·Graciela KrikunCharles Lockwood
Oct 22, 2013·The Lancet Oncology·Martha Hickey
Oct 25, 2011·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Samuel L EngemiseJustin C Konje
Sep 14, 2012·The Cochrane Database of Systematic Reviews·Martha HickeyIan Fraser
Sep 10, 2020·Expert Review of Clinical Pharmacology·Carlo BastianelliGiuseppe Benagiano

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