Endometrial tumors with yolk sac tumor-like morphologic patterns or immunophenotypes: an expanded appraisal

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Oluwole FadareHussain Abubakr

Abstract

Uterine yolk sac tumors have gained increased recognition in recent years. The current study is a multi-faceted examination of yolk sac tumor-like phenotypes in endometrial tumors, based on an analysis of 3 groups of uterine tumors: Group 1: 9 endometrial tumors that had been classified as yolk sac tumor, or as having a yolk sac tumor component, were assessed with a 35-marker immunohistochemical panel, with the goal of defining their immunophenotypic spectrum; Group 2, comprised of 70 endometrial carcinomas of various histotypes, were analyzed for their expression of SALL4, Glypican-3, and AFP, to assess the specificity of these markers for yolk sac tumors relative to endometrial carcinomas; Group 3, comprised of 626 archived cases of endometrial carcinoma/carcinosarcoma, reviewed to define the frequency of yolk sac tumor-like morphology therein. Yolk sac tumor areas in the Group 1 cases were consistently immunoreactive for SALL4 and Glypican-3; variably positive for AFP (89%), Villin (89%), PLAP (78%), 34βE12 (67%), CAM 5.2 (62.5%), EMA (56%), CD117 (50%), p16 (50%), CDX2 (44%), p53 (44% aberrant), MOC31 (37.5%), CK7 (33%), GATA3 (33%), CK5 (25%), and PAX8 (11%); and were negative for CD30, Napsin A, OCT4, estrogen, androgen, ...Continue Reading

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Citations

May 15, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Stephanie L SkalaAndrew P Sciallis
Sep 19, 2020·Seminars in Diagnostic Pathology·Amanda L Strickland, Oluwole Fadare
Mar 27, 2020·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Anjelica HodgsonCarlos Parra-Herran
Aug 4, 2021·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Noah F GomezAshwin S Akki
Aug 8, 2021·The Journal of Pathology. Clinical Research·Viktor ReiswichTill Krech
Mar 27, 2021·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Samuel GrindstaffNatalie Banet
Jun 30, 2021·The American Journal of Surgical Pathology·Ellen DeoletW Glenn McCluggage

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Methods Mentioned

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