Endometrial vascular development in heavy menstrual bleeding: altered spatio-temporal expression of endothelial cell markers and extracellular matrix components

Human Reproduction
Sourima Biswas ShivhareGendie E Lash

Abstract

Are there any phenotypic and structural/architectural changes in the vessels of endometrium and superficial myometrium during the normal menstrual cycle in healthy women and those with heavy menstrual bleeding (HMB)? Spatial and temporal differences in protein levels of endothelial cell (EC) markers and components of the extracellular matrix (ECM) were detected across the menstrual cycle in healthy women and these are altered in HMB. HMB affects 30% of women of reproductive age with ~50% of cases being idiopathic. We have previously shown that the differentiation status of endometrial vascular smooth muscle cells (VSMCs) is altered in women with HMB, suggesting altered vessel maturation compared to controls. Endometrial arteriogenesis requires the co-ordinated maturation not only of the VSMCs but also the underlying ECs and surrounding ECM. We hypothesized that there are spatial and temporal patterns of protein expression of EC markers and vascular ECM components in the endometrium across the menstrual cycle, which are altered in women with HMB. Biopsies containing endometrium and superficial myometrium were taken from hysterectomy specimens from both healthy control women without endometrial pathology and women with subjective...Continue Reading

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Citations

Feb 8, 2020·Physiological Reviews·Hilary O D CritchleyAlistair R W Williams
Jun 4, 2019·Frontiers in Oncology·Rafah A A AlnafakhDharani K Hapangama
Nov 25, 2020·Biomaterials Science·Ines CadenaKaitlin C Fogg
Apr 27, 2021·Frontiers in Cell and Developmental Biology·Qinsheng LuGendie E Lash

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