Endometriosis and cancer: a systematic review and meta-analysis.

Human Reproduction
Marina KvaskoffStacey A Missmer

Abstract

Endometriosis is an often chronic, inflammatory gynaecologic condition affecting 190 million women worldwide. Studies have reported an elevated cancer risk among patients with endometriosis. However, prior research has included methodologic issues that impede valid and robust interpretation. We conducted a meta-analysis of studies investigating the association between endometriosis and cancer risk and analysed the results by methodologic characteristics. We discuss the implications of cancer screening in patients and management challenges faced by clinicians. We searched PubMed and Embase databases for eligible studies from inception through 24 October 2019. We included cohort and case-control studies examining the association between endometriosis and cancer risk; cross-sectional studies and case reports were excluded. Publications had to present risk/rate/odds estimates with 95% CI. Random effects meta-analysis was used to estimate summary relative risks (SRR) and CIs. Heterogeneity across studies was assessed by the Q test and I2 statistics, and publication bias using Egger's and Begg's tests. Risk of bias and quality of the included studies were assessed using the risk of bias in non-randomized studies of interventions (ROB...Continue Reading

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Citations

Apr 11, 2021·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Marina KvaskoffStacey A Missmer
Jul 3, 2021·International Journal of Molecular Sciences·Aintzane Rueda-MartínezIraia García-Santisteban
Jul 25, 2021·International Journal of Molecular Sciences·Imane LalamiDaniel Vaiman
Jul 17, 2021·Gynecologic Oncology·Marjolein HermensRuud L M Bekkers
Aug 19, 2021·Journal of Clinical Laboratory Analysis·Ting ChenShun-Yu Hou

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