Endometriosis and nuclear receptors

Human Reproduction Update
Bahar D Yilmaz, S E Bulun

Abstract

Endometriosis is recognized as a steroid-dependent disorder; however, the precise roles of nuclear receptors (NRs) in steroid responsiveness and other signaling pathways are not well understood. Over the past several years, a number of paradigm-shifting breakthroughs have occurred in the area of NRs in endometriosis. We review and clarify new information regarding the mechanisms responsible for: (i) excessive estrogen biosynthesis, (ii) estrogen-dependent inflammation, (iii) defective differentiation due to progesterone resistance and (iv) enhanced survival due to deficient retinoid production and action in endometriosis. We emphasize the roles of the relevant NRs critical for these pathological processes in endometriosis. We conducted a comprehensive search using PubMed for human, animal and cellular studies published until 2018 in the following areas: endometriosis; the steroid and orphan NRs, estrogen receptors alpha (ESR1) and beta (ESR2), progesterone receptor (PGR), steroidogenic factor-1 (NR5A1) and chicken ovalbumin upstream promoter-transcription factor II (NR2F2); and retinoids. Four distinct abnormalities in the intracavitary endometrium and extra-uterine endometriotic tissue underlie endometriosis progression: dysre...Continue Reading

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Citations

May 7, 2020·Journal of Clinical Medicine·Anna ZubrzyckaMaria Zubrzycka
May 5, 2020·Endocrine Reviews·Md Soriful IslamJames Segars
Feb 11, 2020·Frontiers in Endocrinology·Chloe HoggErin Greaves
Jun 17, 2020·Reproductive Sciences·Yong SongAsgerally T Fazleabas
Feb 18, 2020·Frontiers in Endocrinology·Elizabeth García-GómezMarco Cerbón
Jul 24, 2020·Reproductive Sciences·Huixi ChenFelice Petraglia
Nov 21, 2020·Reproductive Sciences·Essam R OthmanVelja Mijatovic
Jan 5, 2021·Chinese Medical Journal·Feng ZhouSong-Ying Zhang
Jan 10, 2021·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Hiroshi KobayashiShogo Imanaka
Jul 12, 2020·Journal of Gynecology Obstetrics and Human Reproduction·Claudia MassarottiValerio Gaetano Vellone
Jun 4, 2020·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Tomasz SzaflikKrzysztof Szyłło
Nov 7, 2020·International Journal of Molecular Sciences·Beata SmolarzHanna Romanowicz
Dec 7, 2020·Prostaglandins & Other Lipid Mediators·Shenzhi Zhao, Zhangye Xu
Apr 4, 2021·Journal of Clinical Medicine·Jacques Donnez, Marie-Madeleine Dolmans
Nov 25, 2020·Aging·Li JiangXiaoling Fang
Apr 13, 2021·Journal of Food Biochemistry·Zhen LinHuazhong Liu
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Aug 19, 2021·Reviews in Endocrine & Metabolic Disorders·Silvia VannucciniFelice Petraglia
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Sep 19, 2021·Human Reproduction·Eliza M ColgraveJane E Girling
Dec 2, 2021·Human Reproduction·Philippe R KoninckxDan C Martin

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