Endometriosis and ovarian cancer: potential benefits and harms of screening and risk-reducing surgery

Fertility and Sterility
Sun-Wei Guo

Abstract

Although endometriosis is well recognized as a benign gynecologic condition, its association with ovarian cancer (OVCA) has frequently been reported. Review articles on this topic are voluminous, yet there seems to be no consensus as to whether endometriosis is truly a precursor of OVCA and whether any screening or risk-reducing surgery should be instituted, on the basis of our current knowledge. In this review, published data are compiled and critically appraised. Through this critical appraisal, it seems clear that the strongest evidence seems to come from prevalence data. This type of data also suggests a reduced risk of certain histotypes (mainly type II) of OVCA in women with endometriosis. This may explain the rather moderate increase in risk as shown in epidemiologic studies. Even with this moderate increase in OVCA risk, caution should be exercised because of apparent bias in favor of publication of positive results, extensive heterogeneities among prevalence estimates, and inverse relationship between estimates and sizes of the studies. Many molecular studies are conflicting, and earlier studies showing molecular aberrations involved in genomic instability and mutation that enable malignant transformation are not repli...Continue Reading

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Citations

Jan 16, 2016·International Journal of Molecular Sciences·Josep Marí-AlexandreJuan Sandoval
Jul 31, 2016·Homeopathy : the Journal of the Faculty of Homeopathy·Marcus Zulian TeixeiraEdmund Chada Baracat
Jul 16, 2016·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Dingmin YanSun-Wei Guo
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Nov 1, 2018·Reproductive Medicine and Biology·Sun-Wei Guo
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Jun 20, 2020·Human Reproduction Update·Sun-Wei Guo
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