Endometriosis Malignant Transformation: Epigenetics as a Probable Mechanism in Ovarian Tumorigenesis

International Journal of Genomics
Jiaxing HeTianmin Xu

Abstract

Endometriosis, defined as the presence of ectopic endometrial glands and stroma outside the uterine cavity, is a chronic, hormone-dependent gynecologic disease affecting millions of women across the world, with symptoms including chronic pelvic pain, dysmenorrhea, dyspareunia, dysuria, and subfertility. In addition, there is well-established evidence that, although endometriosis is considered benign, it is associated with an increased risk of malignant transformation, with the involvement of various mechanisms of development. More and more evidence reveals an important contribution of epigenetic modification not only in endometriosis but also in mechanisms of endometriosis malignant transformation, including DNA methylation and demethylation, histone modifications, and miRNA aberrant expressions. In this present review, we mainly summarize the research progress about the current knowledge regarding the epigenetic modifications of the relations between endometriosis malignant transformation and ovarian cancer in an effort to identify some risk factors probably associated with ectopic endometrium transformation.

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Citations

Aug 9, 2018·Cancers·Jillian R Hufgard WendelShannon M Hawkins
Apr 25, 2019·International Journal of Molecular Sciences·Konstantinos SapalidisIsaak Kesisoglou
Nov 17, 2019·International Journal of Molecular Sciences·Josep Marí-AlexandreJuan Gilabert-Estellés
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Jun 15, 2021·Frontiers in Endocrinology·Jiajie TuZhiying Yu
Aug 28, 2021·International Journal of Environmental Research and Public Health·Jing-Yang HuangPo-Hui Wang

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Methods Mentioned

BETA
acetylation
ubiquitination
histone acetylation

Software Mentioned

MCA
RDA

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