PMID: 9663459Jul 15, 1998Paper

Endomorphin 1 and 2 have vasodepressor activity in the anesthetized mouse

Peptides
H C ChampionP J Kadowitz

Abstract

The endogenous peptides endomorphin 1 and 2 are newly discovered, potent, selective mu-opioid receptor agonists. In the present study, we investigated responses to the endomorphin peptides in the systemic vascular bed of the anesthetized mouse. Endomorphin 1 and 2 induced dose-related decreases in mean arterial pressure when injected in doses of 3-100 nmol/kg i.v. Mean arterial pressure decreased 14 +/- 4, 23 +/- 4, and 42 +/- 5 mm Hg at the 10, 30, and 100 nmol/kg doses, respectively, of endomorphin 1 (n = 5-7; p < 0.05), and similar changes were observed in response to endomorphin 2. In terms of relative vasodepressor activity, endomorphin 1 and 2 were about equipotent and about threefold more potent than the mu-opioid selective agonist PL017 in decreasing mean arterial pressure; all three peptides decreased heart rate. The time-course of the vasodepressor responses to endomorphin 1 and 2 were similar in rate of onset and decay. Vasodepressor responses to endomorphin 1 and 2 and PL017 but not to nociceptin were inhibited by the opioid receptor antagonist naloxone in a dose of 2 mg/kg i.v. When compared in the mouse and rat, the relative decreases in systemic arterial pressure in response to i.v. injections of endomorphin 1 an...Continue Reading

Citations

Sep 5, 2002·European Journal of Pharmacology·Aly M Abdelrahman, Catherine C Y Pang
Jan 5, 2000·Life Sciences·G HorvathG Benedek
Mar 4, 2000·Peptides·A L VaccarinoA J Kastin
Mar 22, 2002·Clinical and Experimental Pharmacology & Physiology·Hunter C ChampionPhilip J Kadowitz
Mar 11, 2000·The European Journal of Neuroscience·K MonoryA Borsodi
Dec 22, 2009·Diabetes Research and Clinical Practice·Fang-zhen XiaLi-juan Zhao
Nov 9, 2007·Peptides·Weihong Pan, Abba J Kastin
Sep 1, 2016·Journal of Diabetes Research·Juan ZhaoRuilan Niu
Mar 3, 2007·Pharmacological Reviews·Jakub FichnaJean-Claude Do Rego
Jan 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·H C ChampionA L Hyman
Aug 20, 2002·Japanese Journal of Pharmacology·Shinobu SakuradaMasayuki Yuhki

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