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Endomorphin-2- and Neurotensin- Based Chimeric Peptide Attenuates Airway Inflammation in Mouse Model of Nonallergic Asthma

International Journal of Molecular Sciences

Nov 30, 2019

Ewelina RussjanKatarzyna Kaczyńska

Abstract

We examined anti-inflammatory potency of hybrid peptide-PK20, composed of neurotensin (NT) and endomorphin-2 (EM-2) pharmacophores in a murine model of non-atopic asthma induced by skin sensitization with 2,4-dinitrofluorobenzene and intratracheal challenge of cognate hapten. Mice recei...read more

Mentioned in this Paper

Tumor Necrosis Factor-alpha
Immunoreactivity
Lung
Mast Cell
IL2
Peptide Hydrolases
Secretory Phospholipase A2
Neurotensin
TNF
Dinitrofluorobenzene
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Endomorphin-2- and Neurotensin- Based Chimeric Peptide Attenuates Airway Inflammation in Mouse Model of Nonallergic Asthma

International Journal of Molecular Sciences

Nov 30, 2019

Ewelina RussjanKatarzyna Kaczyńska

PMID: 31779093

DOI: 10.3390/ijms20235935

Abstract

We examined anti-inflammatory potency of hybrid peptide-PK20, composed of neurotensin (NT) and endomorphin-2 (EM-2) pharmacophores in a murine model of non-atopic asthma induced by skin sensitization with 2,4-dinitrofluorobenzene and intratracheal challenge of cognate hapten. Mice recei...read more

Mentioned in this Paper

Tumor Necrosis Factor-alpha
Immunoreactivity
Lung
Mast Cell
IL2
Peptide Hydrolases
Secretory Phospholipase A2
Neurotensin
TNF
Dinitrofluorobenzene

Similar Papers Found In These Feeds

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