Abstract
In patients with primary atrioventricular (AV) conduction disturbances, lesions are commonly believed to be limited to the conduction system. In the present study, myocardial lesions were analyzed histologically in patients with AV conduction disturbances to determine the presence of myocarditis. We studied 50 patients with second or third degree AV block in whom the cause was not clear (AVB group). Endomyocardial biopsy was performed from the right ventricle and examined by light microscopy. Tissue specimens also were obtained from 12 normal hearts at autopsy as a control group (N group). The diagnosis of myocarditis was based on the Dallas criteria. The myocyte transverse diameter was 15.4+/-4.1 microm in the AVB group and 11.7+/-3.1 microm in the N group (P<0.01). The fibrosis area ratio also was significantly higher in the AVB group than in the N group (10.1+/-6.7% vs 5.1+/-2.0%). The mean number of lymphocytes per 400-fold magnified field was significantly greater in the AVB group than in the N group (1.9+/-1.6 vs 1.3+/-0.4). In addition, disorganization of the cardiac myocytes was noted in 8 patients in the AVB group (16%), myocyte disarrangement in 39 patients (78%), myocytolysis in 23 patients (46%), and nuclear deformi...Continue Reading
References
Sep 1, 1974·British Heart Journal·D LewesW F Lane
Jul 1, 1970·American Heart Journal·W G Smith
Nov 1, 1982·Japanese Circulation Journal·M TakeK Hirosawa
Mar 1, 1996·Circulation·P RichardsonP Nordet
Nov 5, 1997·American Heart Journal·Y YoshidaT Itoh
Jan 1, 1964·Progress in Cardiovascular Diseases·M LEV
Mar 1, 1964·Progress in Cardiovascular Diseases·J LENEGRE
Citations
Aug 26, 2009·Bulletin of Experimental Biology and Medicine·S A AfanasyevR S Karpov
Nov 18, 2015·Journal of Veterinary Internal Medicine·R A SantilliM Perego
Dec 18, 2013·The American Journal of Cardiology·Christina Y MiyakeDouglas Y Mah
Dec 22, 2011·Lancet·Sandeep SagarLeslie T Cooper
Mar 1, 2011·Journal of Cardiothoracic and Vascular Anesthesia·Vladimir V LomivorotovAlexander M Karaskov
Oct 30, 2010·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·Dennis J TrafnyGordon D Peddle
Aug 11, 2007·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·Whitney M ChurchJames F Zachary
Sep 25, 2008·Pacing and Clinical Electrophysiology : PACE·Yasemin T BozkayaCan Hasdemir
Aug 18, 2012·Pacing and Clinical Electrophysiology : PACE·Sérgio Nuno Craveiro BarraAntónio Leitão Marques
Feb 3, 2015·Irish Veterinary Journal·Izabela JanusKarolina Jabłońska
Nov 6, 2007·Journal of the American College of Cardiology·Leslie T CooperUNKNOWN Heart Failure Association of the European Society of Cardiology
Dec 2, 2009·Korean Circulation Journal·Gyeong-Hee Yoo
Oct 26, 2007·Circulation·Leslie T CooperUNKNOWN European Society of Cardiology
Jun 16, 2011·Circulation. Arrhythmia and Electrophysiology·Leslie T Cooper, Lori A Blauwet
Oct 19, 2013·The Cochrane Database of Systematic Reviews·Huai Sheng ChenJian Ping Liu
May 3, 2019·Heart Failure Reviews·Xiumeng Hua, Jiangping Song
Dec 25, 2015·Heart·Paul Callan, Andrew L Clark
Mar 16, 2017·Journal of Veterinary Internal Medicine·D LuethyA L Johnson
May 8, 2021·Journal of the American College of Radiology : JACR·UNKNOWN Expert Panels on Cardiac Imaging and Neurological ImagingSuhny Abbara