PMID: 9419832Jan 7, 1998Paper

Endopeptidase EC 3.4.24.15 presence in the rat median eminence and hypophysial portal blood and its modulation of the luteinizing hormone surge

Journal of Neuroendocrinology
T J WuJ L Roberts

Abstract

The endopeptidase EC 3.4.24.15 (EP24.15) is a zinc metalloendopeptidase that is widely distributed in a variety of tissues, including the testes, pituitary and the central nervous system. Among its numerous roles in metabolizing and processing biologically-active peptides, the enzyme degrades gonadotropin-releasing hormone (GnRH) by cleaving the central Tyr5-Gly6 bond. The aim of the present studies was to determine whether EP24.15 can modulate the concentrations of GnRH within the hypothalamo-hypophysial portal blood and thereby play a physiological role in reproduction. Our data suggest the presence of immunoreactive EP24.15 in the perivascular space of the median eminence and that this enzyme is secreted into portal blood. We have also shown a physiological role for this enzyme in that an inhibition of its activity with a specific inhibitor augmented the steroid-induced LH increase in ovariectomized rats. The present results suggest that secretory and post-secretory mechanisms are important in shaping the GnRH signal from the central nervous system; GnRH metabolism by EP24.15 may be one such mechanism.

Citations

Dec 15, 2015·Endocrinology·Nicole C WoitowichMarc J Glucksman
Sep 18, 2001·The Journal of Comparative Neurology·J D Fontenele-NetoE S Ferro
Oct 10, 2002·Endocrine Reviews·Corie N ShrimptonRebecca A Lew
Oct 12, 2001·The Journal of Comparative Neurology·E TerasawaJ L Roberts
Apr 6, 2005·The Journal of Pharmacy and Pharmacology·M Kyle HaddenThomas A Dix
Feb 13, 2009·Journal of Neuroendocrinology·T John WuS K Mani
Jan 29, 2008·Experimental Biology and Medicine·Kathryn WaltersT J Wu
Nov 5, 2003·Journal of Neuroscience Research·S I KimM J Glucksman
Mar 7, 2006·Journal of Neurochemistry·Nathaniel A JeskeJames L Roberts
Jun 23, 2016·Journal of Neuroendocrinology·L M RudolphP E Micevych
Sep 2, 2000·The Journal of Biological Chemistry·J W TullaiM J Glucksman
Mar 19, 2005·Journal of Neurochemistry·Flávia R CarreñoEmer S Ferro
Sep 17, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Kirsty Cleverly, T John Wu
Nov 23, 2017·Frontiers in Endocrinology·Bradly M BaumanT John Wu
Jul 17, 2019·Current Medicinal Chemistry·Haralambos TzoupisTheodore Tselios

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