Endophthalmitis Associated With Intravitreal Injections of Anti-VEGF Agents at a Tertiary Referral Center: In-House and Referred Cases

Ophthalmic Surgery, Lasers & Imaging Retina
Nicolas A YannuzziHarry W Flynn

Abstract

To report the incidence rates, causative organisms, and visual acuity (VA) outcomes in patients with endophthalmitis associated with intravitreal injection of anti-vascular endothelial growth factor inhibitors. Retrospective case series between 2005 and 2017. The study included 39 eyes of 39 patients, including 27 (69%) referred and 12 (31%) institutional patients. The use of topical antibiotics after an injection was gradually phased out at the authors' institution, where the preinjection rate of all clinically suspected endophthalmitis was 0.013% (24 of 183,898). The most common isolates were coagulase-negative Staphylococcus and Streptococcus. A VA of 5/200 or better was achieved in 21 of 39 eyes (54%) overall and in two of 15 eyes (13%) infected with Streptococcus. The rate of post-intravitreal injection endophthalmitis is low. Outcomes were generally poor, and the worst were associated with Streptococcus. [Ophthalmic Surg Lasers Imaging Retina. 2018;49:313-319.].

References

Jun 28, 2011·Ophthalmology·Chirag P ShahUNKNOWN Post-Injection Endophthalmitis (PIE) Study Team
Jan 24, 2012·American Journal of Ophthalmology·Roger A GoldbergSerafin Gonzalez
Mar 19, 2014·Ophthalmic Surgery, Lasers & Imaging Retina·John B FiletaHarry W Flynn
Aug 14, 2015·JAMA Ophthalmology·Brian L VanderBeekLiyuan Ma

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Citations

Apr 12, 2020·BMC Ophthalmology·Danny A MammoKaren R Armbrust
Feb 9, 2021·American Journal of Ophthalmology Case Reports·Robert L SteinmetzHarry W Flynn
Dec 16, 2018·American Journal of Ophthalmology·Philip P StoreyUNKNOWN Post-Injection Endophthalmitis (PIE) Study Group
Apr 4, 2021·Journal of Clinical Medicine·Jacob T CoxLucia Sobrin
Jun 3, 2021·Clinical Microbiology Reviews·Sixto M LealPeter H Gilligan
Jun 30, 2021·Ophthalmic Surgery, Lasers & Imaging Retina·Daniela P Reyes-CapoUNKNOWN Endophthalmitis/Anti-VEGF Study Group*
Apr 2, 2020·Case Reports in Ophthalmology·Landon J RohowetzHarry W Flynn

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