Endophthalmitis rates among patients receiving intravitreal anti-VEGF injections: a USA claims analysis

Clinical Ophthalmology
Szilárd KissAdam Turpcu

Abstract

Intravitreal (IVT) injections of the anti-vascular endothelial growth factor (VEGF) agents aflibercept, bevacizumab, and ranibizumab are commonly prescribed to treat neovascular age-related macular degeneration (nAMD). Studies comparing inflammation rates in large populations of patients receiving these agents and the treatment of ocular inflammation post-IVT anti-VEGF injections are scarce. In this study, we compared rates of endophthalmitis claims (sterile and infectious) following IVT anti-VEGF injections to determine the risk factors associated with developing endophthalmitis, and examined the claims for subsequent treatment. This retrospective cohort study of USA claims data examined the risk of developing endophthalmitis following IVT injection of aflibercept, bevacizumab, or ranibizumab in patients with nAMD between 11/18/2011 and 5/31/2013. The primary study outcome was occurrence of endophthalmitis within 30 days of a claim for an IVT anti-VEGF injection. Endophthalmitis rates were calculated separately for aflibercept, bevacizumab, and ranibizumab, followed by pairwise comparisons of endophthalmitis frequencies among the 3 treatments. This analysis included 818,558 injections from 156,594 patients with nAMD. The rates...Continue Reading

Citations

Apr 7, 2020·Eye·Ashish SharmaAnat Loewenstein
Apr 11, 2019·Eye·Ashish SharmaAnat Loewenstein
Sep 12, 2019·Current Diabetes Reports·Avinash HonasogeRithwick Rajagopal
Jun 17, 2020·Ophthalmology Retina·Ryan A ShieldsTarek S Hassan
Jan 11, 2020·Survey of Ophthalmology·Shriji N PatelStephen J Kim
Jun 30, 2021·Ophthalmic Surgery, Lasers & Imaging Retina·Dilsher S DhootNamrata Saroj
Jul 30, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Laiqing XieManhui Zhu
Nov 23, 2020·Ophthalmology Retina·Ferhina S AliUNKNOWN Post-Injection Endophthalmitis Study Group
Aug 15, 2021·Expert Opinion on Drug Delivery·Arshad M KhananiPeter K Kaiser
Apr 2, 2020·Case Reports in Ophthalmology·Landon J RohowetzHarry W Flynn

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