Endoplasmic Reticulum-Mitochondrial Ca(2+) Fluxes Underlying Cancer Cell Survival

Frontiers in Oncology
Hristina IvanovaGeert Bultynck

Abstract

Calcium ions (Ca(2+)) are crucial, ubiquitous, intracellular second messengers required for functional mitochondrial metabolism during uncontrolled proliferation of cancer cells. The mitochondria and the endoplasmic reticulum (ER) are connected via "mitochondria-associated ER membranes" (MAMs) where ER-mitochondria Ca(2+) transfer occurs, impacting the mitochondrial biology related to several aspects of cellular survival, autophagy, metabolism, cell death sensitivity, and metastasis, all cancer hallmarks. Cancer cells appear addicted to these constitutive ER-mitochondrial Ca(2+) fluxes for their survival, since they drive the tricarboxylic acid cycle and the production of mitochondrial substrates needed for nucleoside synthesis and proper cell cycle progression. In addition to this, the mitochondrial Ca(2+) uniporter and mitochondrial Ca(2+) have been linked to hypoxia-inducible factor 1α signaling, enabling metastasis and invasion processes, but they can also contribute to cellular senescence induced by oncogenes and replication. Finally, proper ER-mitochondrial Ca(2+) transfer seems to be a key event in the cell death response of cancer cells exposed to chemotherapeutics. In this review, we discuss the emerging role of ER-mit...Continue Reading

References

Aug 1, 1992·Archives of Biochemistry and Biophysics·G G ChangC L Meng
Nov 20, 1997·The Journal of Biological Chemistry·D H MacLennanN M Green
Feb 9, 2000·American Journal of Physiology. Cell Physiology·P R TerritoR S Balaban
Feb 28, 2002·Frontiers in Bioscience : a Journal and Virtual Library·Feliciano Protasi
Sep 25, 2002·Physiological Reviews·Michael Fill, Julio A Copello
Dec 23, 2004·Proceedings of the National Academy of Sciences of the United States of America·Scott A OakesStanley J Korsmeyer
Apr 15, 2005·Redox Report : Communications in Free Radical Research·Yi Zheng, Xun Shen
May 20, 2005·Nature·Tilman OltersdorfSaul H Rosenberg
Sep 24, 2005·Nature Cell Biology·Carl WhiteJ Kevin Foskett
Jul 11, 2006·Biochimica Et Biophysica Acta·Dmitry B ZorovSteven J Sollott
Dec 21, 2006·The Journal of Cell Biology·György SzabadkaiRosario Rizzuto
Jan 25, 2007·Molecular Cell·Maria Høyer-HansenMarja Jäättelä
Jul 20, 2007·Proceedings of the National Academy of Sciences of the United States of America·Chi LiCarl White
Feb 6, 2008·Proceedings of the National Academy of Sciences of the United States of America·Tania SzadoH Llewelyn Roderick
Apr 25, 2008·Nature Reviews. Cancer·H Llewelyn Roderick, Simon J Cook
May 20, 2008·The Journal of Biological Chemistry·Wayne I DeHavenJames W Putney
Aug 30, 2008·Biochemical and Biophysical Research Communications·Saverio MarchiPaolo Pinton
Sep 25, 2008·Nature Reviews. Molecular Cell Biology·Helfrid HocheggerTim Hunt
Oct 8, 2008·Proceedings of the National Academy of Sciences of the United States of America·G M CereghettiL Scorrano
Nov 18, 2008·Biochimica Et Biophysica Acta·Michael J Berridge
Apr 21, 2009·International Journal of Biological Macromolecules·Prasanna K DadiZulfiqar Ahmad
Jul 21, 2009·Proceedings of the National Academy of Sciences of the United States of America·Kasturi MitraJennifer Lippincott-Schwartz
Jul 21, 2009·Proceedings of the National Academy of Sciences of the United States of America·Toren Finkel, Paul M Hwang
Jul 23, 2009·Proceedings of the National Academy of Sciences of the United States of America·Alessandro RimessiRosario Rizzuto
Aug 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Yi-Ping RongClark W Distelhorst
Oct 10, 2009·Nature Protocols·Mariusz R WieckowskiPaolo Pinton
Mar 7, 1927·The Journal of General Physiology·O WarburgE Negelein
Jul 7, 2010·Molecular Cell·György CsordásGyörgy Hajnóczky
Sep 24, 2010·Journal of Nucleic Acids·Claus DeslerLene Juel Rasmussen

❮ Previous
Next ❯

Citations

May 16, 2019·Cold Spring Harbor Perspectives in Biology·Sarah J Roberts-ThomsonGregory R Monteith
Sep 7, 2019·Proceedings of the National Academy of Sciences of the United States of America·Chentao GeCaiyun Fu
Sep 5, 2017·Frontiers in Oncology·Maria Livia SassanoPatrizia Agostinis
May 22, 2020·Molecular and Cellular Biochemistry·Muhammad AfzalKhalil Ahmed
Oct 10, 2018·Frontiers in Physiology·Carolina Jaquenod De GiustiSamarjit Das
Mar 14, 2019·Cancers·Maxence Le VasseurChristian C Naus
Jun 23, 2019·International Journal of Molecular Sciences·Elizabeth VargheseDietrich Büsselberg
Aug 14, 2020·Cancers·Laura CaraviaSilviu Cristian Voinea
Feb 8, 2021·Biochimica Et Biophysica Acta. Molecular Cell Research·Ian de RidderGeert Bultynck
Mar 9, 2021·Trends in Cell Biology·Jens LonckeGeert Bultynck
Jul 17, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Chenrui LiLin Sun
May 1, 2021·International Journal of Environmental Research and Public Health·Shuang-Shuang ZhangJun-Ping Li
Apr 30, 2021·Journal of Cell Science·Pawel MozolewskiRadek Dobrowolski
Apr 20, 2021·Frontiers in Cell and Developmental Biology·Yanguo XinXiaojing Liu
May 3, 2019·Pharmacology & Therapeutics·Tanweer HaiderVandana Soni
Aug 28, 2021·Cellular and Molecular Life Sciences : CMLS·Monika PichlaMartijn Kerkhofs

❮ Previous
Next ❯

Methods Mentioned

BETA
xenograft
GTPases

Related Concepts

Related Feeds

Autophagy & Metabolism

Autophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones. In starvation, it provides an internal source of nutrients for energy generation and, thus, survival. A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however--cancer cells exploit it to survive in nutrient-poor tumors.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

Cancer Metabolism: Therapeutic Targets

Targeting the mechanisms by which cancer cells acquire energy for metabolic needs is a therapeutic target. Discover the latest research on cancer metabolism and therapeutic targets.