Endoplasmic reticulum quality control in cancer: Friend or foe

Seminars in Cancer Biology
Hana KimLing Qi

Abstract

Quality control systems in the endoplasmic reticulum (ER) mediated by unfolded protein response (UPR) and endoplasmic reticulum associated degradation (ERAD) ensure cellular function and organismal survival. Recent studies have suggested that ER quality-control systems in cancer cells may serve as a double-edged sword that aids progression as well as prevention of tumor growth in a context-dependent manner. Here we review recent advances in our understanding of the complex relationship between ER proteostasis and cancer pathology, with a focus on the two most conserved ER quality-control mechanisms--the IRE1α-XBP1 pathway of the UPR and SEL1L-HRD1 complex of the ERAD.

References

Aug 7, 2003·Proceedings of the National Academy of Sciences of the United States of America·Ann-Hwee LeeLaurie H Glimcher
Sep 10, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Paola GranelliIda Biunno
Dec 22, 2004·The Journal of Biological Chemistry·Naoko YagishitaToshihiro Nakajima
Dec 8, 2005·Neoplasia : an International Journal for Oncology Research·Monica CattaneoIda Biunno
Jun 8, 2006·Annual Review of Biochemistry·Fabrizio Chiti, Christopher M Dobson
Jul 11, 2006·Science·Julie Hollien, Jonathan S Weissman
Oct 13, 2006·Molecular and Cellular Biology·Maiko OgataKazunori Imaizumi
Oct 18, 2006·The Journal of Cell Biology·Britta MuellerHidde L Ploegh
Jan 30, 2007·Experimental and Molecular Pathology·Baruch D Jakubovic, Serge Jothy
Apr 10, 2007·Cancer Cell·Daniel R CarrascoRonald A DePinho
Jun 15, 2007·Nature Reviews. Molecular Cell Biology·David Ron, Peter Walter
Jan 15, 2008·Cell·Beth Levine, Guido Kroemer
Aug 20, 2008·Proceedings of the National Academy of Sciences of the United States of America·Britta MuellerHidde L Ploegh
Aug 30, 2008·The New England Journal of Medicine·Jesús F San MiguelUNKNOWN VISTA Trial Investigators
Aug 5, 2009·The Journal of Cell Biology·Julie HollienJonathan S Weissman
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Takao IwawakiKenji Kohno
Nov 12, 2009·Journal of Cell Science·Benedict C S CrossEileithyia Swanton
Feb 23, 2010·BMC Developmental Biology·Shuai LiQiaoming Long
Oct 23, 2010·Molecular Cell·Guido KroemerBeth Levine
Feb 19, 2011·Genes & Cancer·Yien Che Tsai, Allan M Weissman
Jun 28, 2011·Trends in Endocrinology and Metabolism : TEM·Haibo ShaLing Qi
Feb 9, 2012·Proceedings of the National Academy of Sciences of the United States of America·Benedict C S CrossHeather P Harding
Feb 22, 2012·Digestive Diseases and Sciences·Hassan AshktorabIda Biunno
May 9, 2012·Proceedings of the National Academy of Sciences of the United States of America·Kenjiro SakakiRandal J Kaufman

❮ Previous
Next ❯

Citations

Jan 9, 2016·Biochemical and Biophysical Research Communications·Chun JinChen-Guo Zheng
Dec 5, 2015·Frontiers in Oncology·Paul EggletonEdwin Bremer
Oct 23, 2015·Mediators of Inflammation·Claudia GiampietriElio Ziparo
May 11, 2015·Seminars in Cancer Biology·Claudio Hetz, Eric Chevet
Sep 16, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Younis Mohammad HazariKhalid Majid Fazili
Feb 22, 2017·Fish & Shellfish Immunology·Xiangqin WangChengyu Hu
Feb 9, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Milan HanoZdena Sulová
Feb 13, 2018·Oxidative Medicine and Cellular Longevity·Yoon Seon YooYoung Joo Jeon
Aug 23, 2018·Journal of Cell Science·Sara SanninoJeffrey L Brodsky
Sep 1, 2015·Circulation Research·Haipeng SunYibin Wang
Sep 29, 2020·Frontiers in Cell and Developmental Biology·Litian ZhangLiang Chen
May 26, 2017·Frontiers in Cell and Developmental Biology·Dan LindholmSulev Kõks
Oct 31, 2019·Journal of Oncology·Gábor TaxPietro Roversi
Nov 18, 2017·BMC Biology·Sara Sannino, Jeffrey L Brodsky
May 22, 2019·The Journal of Pathology. Clinical Research·Marta MellaiDavide Schiffer
Jun 15, 2019·Journal of Cancer Research and Clinical Oncology·Kai BachmannKatharina Grupp
Mar 24, 2020·Seminars in Cancer Biology·Mohd IshaqShrawan K Singh
Jul 24, 2018·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Dohee KwonDoo Hyun Chung
Aug 28, 2021·Journal of Cellular Physiology·Prashant KumarAmit Mishra

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Ataxia telangiectasia (MDS)

Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

Autophagy & Metabolism

Autophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones. In starvation, it provides an internal source of nutrients for energy generation and, thus, survival. A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however--cancer cells exploit it to survive in nutrient-poor tumors.

Ataxias

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on different types of ataxias here.

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Autophagy & Disease

Autophagy is an important cellular process for normal physiology and both elevated and decreased levels of autophagy are associated with disease. Here is the latest research.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Adenomatous Polyposis Coli

Adenomatous polyposis coli is a protein encoded by the APC gene and acts as a tumor suppressor. Discover the latest research on adenomatous polyposis coli here.

Cancer Stem Cells in Glioblastoma

Glioblastoma is the most common and aggressive type of brain tumor. It contains a population of tumor initiating stem cell-like cells known as cancer stem cells. Investigations are ongoing into these cancer stem cells found in these solid tumors which are highly resistance to treatment. Here is the latest research on cancer stem cells in glioblastoma.

Breast Tumorigenesis

Breast tumorigenesis involves the production or formation of tumor(s) in breast tissue. Discover the latest research on breast tumorigenesis here.

Parkinson's Disease & Autophagy (MDS)

Autophagy leads to degradation of damaged proteins and organelles by the lysosome. Impaired autophagy has been implicated in several diseases. Here is the role of autophagy in Parkinson’s disease.

Alzheimer's Disease: Transcription

Impaired transcription is associated with the pathogenesis and progression of conditions such as Alzheimer's disease (AD). Here are the latest discoveries pertaining to transcription and AD.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

© 2021 Meta ULC. All rights reserved