Endoplasmic reticulum stress: a novel mechanism and therapeutic target for cardiovascular diseases

Acta Pharmacologica Sinica
Mei-Qing LiuLin-Xi Chen

Abstract

Endoplasmic reticulum is a principal organelle responsible for folding, post-translational modifications and transport of secretory, luminal and membrane proteins, thus palys an important rale in maintaining cellular homeostasis. Endoplasmic reticulum stress (ERS) is a condition that is accelerated by accumulation of unfolded/misfolded proteins after endoplasmic reticulum environment disturbance, triggered by a variety of physiological and pathological factors, such as nutrient deprivation, altered glycosylation, calcium depletion, oxidative stress, DNA damage and energy disturbance, etc. ERS may initiate the unfolded protein response (UPR) to restore cellular homeostasis or lead to apoptosis. Numerous studies have clarified the link between ERS and cardiovascular diseases. This review focuses on ERS-associated molecular mechanisms that participate in physiological and pathophysiological processes of heart and blood vessels. In addition, a number of drugs that regulate ERS was introduced, which may be used to treat cardiovascular diseases. This review may open new avenues for studying the pathogenesis of cardiovascular diseases and discovering novel drugs targeting ERS.

References

Jan 1, 1997·Annual Review of Physiology·J Sadoshima, S Izumo
Nov 24, 1998·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·J M Malinowski
Nov 30, 2000·The Journal of Biological Chemistry·G R Crabtree
Nov 9, 2001·Annual Review of Genetics·S W FewellJ L Brodsky
Jul 27, 2002·Annual Review of Cell and Developmental Biology·Heather P HardingDavid Ron
Mar 4, 2003·Nature Reviews. Molecular Cell Biology·Lars Ellgaard, Ari Helenius
Apr 22, 2003·Journal of Cellular Biochemistry·Yoshifumi WatanabeToshihiro Akaike
May 17, 2003·The Journal of Clinical Investigation·Detlef WenckerRichard N Kitsis
Oct 18, 2003·Science·Feroz R PapaPeter Walter
Feb 7, 2004·The EMBO Journal·Lingfang ZengJohn Y-J Shyy
Oct 7, 2004·European Journal of Pharmacology·Xing Zu ZhuJin Liu
Feb 3, 2005·Current Opinion in Nephrology and Hypertension·Rhian M Touyz
Aug 2, 2005·Nature Cell Biology·Birgit MeusserThomas Sommer
Oct 4, 2005·The Journal of Clinical Investigation·Chunyan XuJohn C Reed
Jan 18, 2006·Journal of the American College of Cardiology·Srikanth SolaBobby V Khan

❮ Previous
Next ❯

Citations

Oct 1, 2018·Journal of Cellular Biochemistry·Quan-Fang ChenXiang-Tao Zeng
Aug 3, 2018·Journal of Cellular Physiology·Zhen HuangLinxi Chen
Nov 6, 2018·Journal of Cellular Physiology·Zhen HuangLinxi Chen
Aug 11, 2017·Journal of Cellular Physiology·Zhen HuangLinxi Chen
Jan 22, 2020·Physiological Genomics·Mitchell C LockJanna L Morrison
Apr 14, 2017·Acta Biochimica Et Biophysica Sinica·Jiaqi LiuLinxi Chen
Jan 5, 2019·Physiological Research·T Stracina, M Novakova
Mar 5, 2020·Cellular and Molecular Life Sciences : CMLS·Jialong YanLinxi Chen
May 22, 2019·International Journal of Molecular Sciences·Paloma Gómez-FernándezKoen Vandenbroeck
Dec 1, 2019·International Journal of Molecular Sciences·Jehad Z TayyebJogchum Plat
Jun 10, 2017·Basic Research in Cardiology·Stefanie Meyer-RoxlauAli El-Armouche
Sep 7, 2017·International Journal of Vascular Medicine·Junyoung HongYoonjung Park
Mar 22, 2018·Frontiers in Molecular Neuroscience·Daiqiang LiuFeng Gao
Feb 20, 2020·Molecular Biology Reports·Nur Banu BalEmine Demirel-Yilmaz
Feb 24, 2017·Apoptosis : an International Journal on Programmed Cell Death·Zhimin ZhangWei Li
Aug 28, 2020·International Journal of Molecular Sciences·Fatin Farhana JubaidiSiti Balkis Budin
Oct 22, 2020·Acta Biochimica Et Biophysica Sinica·Rongji MaHailong Lv
Mar 1, 2021·Neuropeptides·Jia-Xiu ZhouShao-Wen Tian
Feb 3, 2021·European Journal of Clinical Investigation·Thamonwan DiteepengMarco Luciani
Jun 28, 2020·Cellular Signalling·Khadeja-Tul KubraNektarios Barabutis
Sep 6, 2020·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Pavlo V ZadorozhniiAleksandr V Kharchenko
Apr 30, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Si ChenPeng Li
Apr 27, 2021·Journal of Receptor and Signal Transduction Research·Mustafa Kırça, Akın Yeşilkaya
May 1, 2021·International Journal of Molecular Sciences·Helena KratochvílováMartin Haluzík

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.