Endoplasmic reticulum stress in the development of multiple myeloma and drug resistance

Clinical & Translational Immunology
Nicholas NikesitchTara Laurine Roberts

Abstract

Multiple myeloma (MM) is a haematological malignancy of mature antibody-secreting plasma cells. Currently, MM is incurable, but advances in drug treatments have increased patient lifespan. One of the characteristics of MM is the excessive production of monoclonal immunoglobulin (also referred to as paraprotein). This high level of protein production induces endoplasmic reticulum (ER) stress, and proteasomal degradation of the paraprotein is required to avoid ER stress-induced cell death. Consequently, proteasomal inhibitors such as bortezomib have been particularly effective therapies. Unfortunately development of resistance to bortezomib is common. In this review, we address how control of endoplasmic reticulum stress is important in the development of MM and how the unfolded protein response and its associated stress response pathways are involved in the development of bortezomib resistance.

References

Oct 19, 2001·Oncogene·P L Bergsagel, W M Kuehl
Nov 21, 2002·Biochemical Society Transactions·N Kedersha, P Anderson
Nov 26, 2002·Molecular and Cellular Biology·Monica G MarcuLen Neckers
Jan 17, 2003·Mayo Clinic Proceedings·Robert A KylePhilip R Greipp
Feb 11, 2003·Cell Structure and Function·Noboru MizushimaTamotsu Yoshimori
Sep 11, 2003·The Lancet Oncology·Sonja SeidlJohannes Drach
Jun 15, 2005·Annual Review of Biochemistry·Martin Schröder, Randal J Kaufman
Oct 4, 2005·The Journal of Clinical Investigation·Chunyan XuJohn C Reed
Jun 2, 2006·Journal of the American Society of Nephrology : JASN·Stewart H LeckerWilliam E Mitch
Apr 10, 2007·Cancer Cell·Daniel R CarrascoRonald A DePinho
Jul 13, 2007·Cancer Chemotherapy and Pharmacology·Jon PattersonEmmanuel Normant
Nov 17, 2007·Genes & Development·Noboru Mizushima
Jun 11, 2009·Molecular Cancer Therapeutics·Bao HoangAlan Lichtenstein
Feb 11, 2010·International Journal of Cell Biology·Tom VerfailliePatrizia Agostinis
Mar 13, 2010·Seminars in Cell & Developmental Biology·Davide ElettoYair Argon
Mar 25, 2011·Nature·Michael A ChapmanTodd R Golub
Apr 13, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Evangelos TerposMeletios A Dimopoulos
May 25, 2011·Journal of the National Cancer Institute·Amy M RuschakAaron D Schimmer
Sep 1, 2011·Molecular Cancer Therapeutics·Zhineng J YangFrank A Sinicrope
Sep 14, 2011·Molecular and Cellular Biology·James A L BrownMartin F Lavin
Jan 19, 2012·Nature Reviews. Molecular Cell Biology·Claudio Hetz

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Citations

Oct 28, 2019·Clinical and Experimental Medicine·Mitsuki TabataShozo Nishida
Feb 7, 2020·International Journal of Hematology·Yusuke Furukawa, Jiro Kikuchi
Sep 4, 2020·International Journal of Molecular Sciences·Yusuke YamashitaShinobu Tamura
Aug 14, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Sun-Ji ParkYing Maggie Chen
May 17, 2018·Frontiers in Endocrinology·Mariah L Farrell, Michaela R Reagan
Nov 14, 2019·International Journal of Molecular Sciences·Yurong GaoJaemin Lee
May 2, 2019·Frontiers in Cell and Developmental Biology·Alfonso Serrano-Del ValleIsabel Marzo
Sep 8, 2019·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Teodora Alexa-StratulatChiara Riganti
May 28, 2020·Trends in Cancer·Emma C MaddenAfshin Samali
Jan 12, 2021·Journal of Experimental & Clinical Cancer Research : CR·Muhlis AkmanChiara Riganti
Feb 19, 2021·Cellular and Molecular Life Sciences : CMLS·Sinan XiongJianbiao Zhou
Mar 16, 2021·Biochemical Engineering Journal·Manibarathi VaithiyanathanAdam T Melvin
Apr 7, 2021·Blood Advances·Brittany C LipchickMikhail A Nikiforov
Apr 10, 2021·Frontiers in Oncology·Rodrigo Carlini FernandoGisele Wally Braga Colleoni
Jul 3, 2021·Current Oncology·Denisa Weiser Drozdkova, Katerina Smesny Trtkova
Dec 10, 2021·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Katrina A HarmonSuzanne Fanning

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Methods Mentioned

BETA
protein folding

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