Endorectal ultrasound of T3 and T4 rectal cancers after preoperative chemoradiation

Diseases of the Colon and Rectum
P R WilliamsonA Ferrara

Abstract

This study was undertaken to assess the accuracy and ability of endorectal ultrasound (ERUS) to predict changes in rectal tumor stage after a preoperative chemoradiation protocol. Since December 1990, all rectal malignancies at our institution have been preoperatively staged with ERUS. ERUS has been an essential tool in preoperative staging of rectal cancer patients, possessing an overall accuracy of 84 percent for T stage and 81 percent for lymph node status in our hands (Williamson PR, unpublished data). Beginning in July 1992, all patients staged with T3 or T4 lesions on initial ERUS have been entered into a protocol consisting of preoperative chemoradiation therapy (CRT). This protocol consists of patients receiving 4,500 to 5,040 rads for five to eight weeks and concomitantly receiving sensitizing doses of 5-fluorouracil and/or leucovorin. All patients were scheduled for sphincter-saving or abdomino-perineal resections six to eight weeks following completion of CRT. A repeat ERUS was performed on each patient one week before surgery. The study group consisted of 15 patients who completed CRT, including 12 males and 3 females. Evidence of tumor shrinkage via ERUS measurement was seen in all patients. Average tumor shrinkage...Continue Reading

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Citations

Sep 30, 2006·European Radiology·Christian KlessenMatthias Taupitz
Sep 12, 2007·Diseases of the Colon and Rectum·Filippo Grillo-RuggieriStefano Cascinu
Jan 13, 2011·La Radiologia medica·F SaniP Torricelli
Jul 8, 2000·Surgical Oncology·C S LimJ R Monson
Oct 3, 1999·The British Journal of Surgery·J M WheelerN J Mortensen
Mar 27, 2002·The American Journal of Surgical Pathology·Nicolas LeupinLuca Mazzucchelli
Mar 3, 2006·Journal of Gastroenterology and Hepatology·Yaakov MaorBenjamin Avidan
Aug 13, 2011·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·R S J DaltonI R Daniels
Jul 23, 2005·Oncology·Young S OhRiad R Azar
Jun 27, 2012·AJR. American Journal of Roentgenology·Vivek Gowdra HalappaIhab R Kamel
Jul 9, 2008·Acta Oncologica·Katrine J Emmertsen, Søren Laurberg
Jul 26, 2011·Clinics and Research in Hepatology and Gastroenterology·Pietro MaroneGiovanni Battista Rossi
Jul 1, 2008·Journal of the American College of Surgeons·Jung Wook HuhSeung-Kook Sohn
Jan 4, 2006·Surgical Oncology Clinics of North America·Josh Kehoe, Vijay P Khatri
Apr 22, 2015·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·S MemonA G Heriot
May 1, 1997·Diseases of the Colon and Rectum·A Shafik
Jan 27, 2016·World Journal of Gastroenterology : WJG·Daniel G Couch, David M Hemingway
Jan 5, 2002·Annals of Surgical Oncology·M W OnaitisD S Tyler
May 24, 2006·World Journal of Gastroenterology : WJG·Glen-C BalchJose-G Guillem
Nov 17, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Marleen J E M GosensIris D Nagtegaal

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