Endoscopic and clinical features of gastric ulcers in Japanese patients with or without Helicobacter pylori infection who were using NSAIDs or low-dose aspirin.

Journal of Gastroenterology
Yongmin KimHiroto Miwa

Abstract

The endoscopic characteristics of gastric ulcers in patients who were using non-steroidal anti-inflammatory drugs (NSAIDs) or low-dose aspirin (LDA) and were infected with Helicobacter pylori remain unclear. We elucidated the endoscopic characteristics of gastric ulcers that occurred in the presence or absence of H. pylori infection and were associated with the use of these drugs. A total of 379 patients with active-stage gastric ulcer were divided into three groups: H. pylori-positive patients using neither NSAIDs nor LDA (control group, n = 216), H. pylori-positive or -negative patients using NSAIDs (NSAIDs group, n = 100), and H. pylori-positive or -negative patients using LDA (LDA group, n = 63). The differences among these groups in endoscopic characteristics of the ulcers (site, multiplicity, and morphology) were determined. The influence of an antacid drug, i.e., a proton pump inhibitor (PPI) or a histamine H(2) receptor antagonist (H(2)RA), was also investigated. The NSAIDs group, regardless of H. pylori infection status, had higher incidences of antral, multiple, and irregularly shaped ulcers. The LDA group had a higher incidence of antral ulcers in H. pylori-negative patients and, regardless of H. pylori infection sta...Continue Reading

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Citations

Feb 9, 2016·Scandinavian Journal of Gastroenterology·Katsunori IijimaTooru Shimosegawa
Jun 12, 2013·Asian Journal of Surgery·Atul K SharmaTej Pratap Singh
Jan 12, 2021·Curēus·Abdullah M AlmuebidDunya Alfaraj
Sep 11, 2021·ANZ Journal of Surgery·Satish Subbiah NagarajSreedhara B Chaluvashetty

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