Endoscopic and operative palliation strategies for pancreatic ductal adenocarcinoma

Seminars in Oncology
Alexander Stark, O Joe Hines

Abstract

Malignant biliary obstruction, duodenal, and gastric outlet obstruction, and tumor-related pain are the complications of unresectable pancreatic adenocarcinoma that most frequently require palliative intervention. Surgery involving biliary bypass with or without gastrojejunostomy was once the mainstay of treatment in these patients. However, advances in non-operative techniques-most notably the widespread availability of endoscopic biliary and duodenal stents-have shifted the paradigm of treatment away from traditional surgical management. Questions regarding the efficacy and durability of endoscopic stents for biliary and gastric outlet obstruction are reviewed and demonstrate high rates of therapeutic success, low rates of morbidity, and decreased cost. Surgery remains an effective treatment modality, and still produces the most durable relief in appropriately selected patients.

References

Jan 1, 1994·American Journal of Surgery·T P WadeF E Johnson
Mar 18, 2000·Archives of Surgery·A PietrabissaF Mosca
May 16, 2000·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·A Schwarz, H G Beger
Oct 18, 2002·Surgical Endoscopy·T A AlamM C Parker
Apr 19, 2005·The Surgical Clinics of North America·Michael G House, Michael A Choti
Jun 15, 2007·BMC Gastroenterology·Suzanne M JeurninkPeter D Siersema
Aug 21, 2007·Endoscopy·I GraberUNKNOWN Société Française d'Endoscopie Digestive (SFED)
Jun 25, 2009·Surgical Endoscopy·Jasen LyJohn A Windsor
Jul 11, 2009·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Edwina N ScottDavid P Berry
Jan 15, 2010·The New England Journal of Medicine·Niels A van der GaagDirk J Gouma
Feb 23, 2010·Surgical Endoscopy·Rodrigo CastañoEverson L A Artifon
Mar 8, 2011·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Suzanne M JeurninkUNKNOWN Dutch SUSTENT Study Group
Sep 8, 2011·Surgical Endoscopy·Manju D ChandrasegaramMichael R Cox
Feb 3, 2012·Endoscopy·J-M DumonceauUNKNOWN European Society of Gastrointestinal Endoscopy
Feb 7, 2012·Journal of Surgical Oncology·Phillip J GrayJoseph M Herman
Jun 8, 2012·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·John M LyonsPeter J Allen
Jan 7, 2015·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal

❮ Previous
Next ❯

Citations

Feb 7, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Thierry ConroyMichel Ducreux
Sep 1, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M DucreuxUNKNOWN ESMO Guidelines Committee
Apr 21, 2016·Cancers·Daniel ZeitouniKirsten L Bryant
Nov 30, 2016·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·R VeraJ L Manzano
Aug 6, 2019·Cancer·Gordon T MoffatEileen M O'Reilly
Dec 21, 2016·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·M HidalgoAlfredo Carrato
Aug 11, 2018·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·M BrunnerG F Weber
Aug 16, 2019·World Journal of Gastroenterology : WJG·Andrea AnderloniAlessandro Repici
Jun 15, 2017·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·B LaquenteA Carrato
Jan 23, 2021·International Journal of Surgery Case Reports·Hideki KogoHiroshi Yoshida
Jun 2, 2021·Seminars in Oncology·Johannes KloseJörg Kleeff
Aug 8, 2021·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Alessandro FugazzaAndrea Anderloni

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

Cachexia & Brown Fat

Cachexia is a condition associated with progressive weight loss due to severe illness. In cancer patients, it is proposed to occur as a result of tumor-induced energy wasting. Several proteins have been implicated in browning and depletion of white adipose tissue. Here is the latest research on cachexia and brown fat.

Cardiac Cachexia

Cardiac cachexia is a syndrome associated with the progressive loss of muscle and fat mass. It most commonly affects patients with heart failure and can significantly decrease the quality of life and survival in these patients. Here is the latest research on cardiac cachexia.