Abstract
To describe the endoscopic characteristics of renal papillae in struvite stone formers (SFs). From 2009 to 2014, patients undergoing percutaneous nephrolithotomy were prospectively enrolled in our study. Endoscopic analysis and biopsy of papillae were performed to demonstrate the presence and percentage surface area (SA) of Randall's plaque or ductal plug. Comparison with idiopathic calcium oxalate (CaOx) SF and non-SF controls was performed. We identified 29 struvite SFs to compare with 90 idiopathic CaOx SFs and 17 controls. On endoscopic mapping, 28 struvite SFs (97%) demonstrated Randall's plaque and 9 (31%) had plugging. The average mean SA of Randall's plaque in struvite SF (1.5 ± 1.4%) was less than CaOx SFs (3.7 ± 4.3%, P = .0018) and similar to controls (1.7 ± 2.7%, P = .76). Average mean plug SA was similar between struvite SFs, CaOx SFs, and controls. On metabolic assessment, 83% of struvite SFs had at least one urine abnormality, with urinary uric acid and oxalate levels significantly higher among struvite SFs compared to controls (P = .002). Despite lack of active urinary tract infection, interstitial inflammation was more prevalent in struvite SFs compared to CaOx SFs (43.5% vs 7.3%, P = .0001). Our findin...Continue Reading
References
Jan 1, 1983·Medicine·D E Silverman, T A Stamey
May 1, 1995·The Journal of Urology·J M TeichmanJ C Hulbert
Nov 20, 1997·The Journal of Urology·R K Low, M L Stoller
Nov 9, 2000·BJU International·S Choong, H Whitfield
Feb 7, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G GambaroA D'Angelo
Jul 24, 2002·International Journal of Antimicrobial Agents·K-H BichlerS Lahme
Apr 8, 2003·Current Pharmaceutical Design·Nadeem U RahmanMarshall L Stoller
Nov 25, 2003·Kidney International·Ramsay L KuoFredric L Coe
Jan 28, 2005·Kidney International·Andrew P EvanMarc Grynpas
Apr 8, 2006·The Journal of Urology·Brian R MatlagaJames E Lingeman
Apr 15, 2006·Kidney International·A EvanE Worcester
Feb 1, 2007·Kidney International·A P EvanE Worcester
Aug 7, 2007·The Urologic Clinics of North America·Kelly A Healy, Kenneth Ogan
May 2, 2008·Kidney International·Andrew E EvanElaine M Worcester
Nov 22, 2008·BJU International·Nicole L MillerJames E Lingeman
Aug 28, 2009·Kidney International·Andrew P EvanElaine M Worcester
Oct 27, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Nathan A SaucierJohn C Lieske
Dec 24, 2009·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Carmen R P AmaroJoao L Amaro
Apr 23, 2010·Urological Research·Fredric L CoeJames E Lingeman
Jun 22, 2012·European Urology·Simon N Thornton
Oct 6, 2012·European Urology·Hans-Göran Tiselius
May 24, 2013·Kidney International·Michael P LinnesJohn C Lieske
Jun 25, 2013·Urology·Amy E KrambeckTerri J Vrtiska
Oct 15, 2013·The Journal of Urology·Dean G Assimos
Oct 4, 2014·Clinical Journal of the American Society of Nephrology : CJASN·John C LieskeThomas P Moyer
Citations
Aug 24, 2016·Nature Reviews. Urology·Michael S BorofskyJames E Lingeman
May 31, 2018·International Urology and Nephrology·Saritha RanabothuBeth A Drzewiecki
Dec 28, 2019·Journal of Endourology·Andrew P EvanJames E Lingeman
Jan 6, 2019·World Journal of Urology·Maria Sloth PlessPalle Jörn Sloth Osther
Nov 25, 2018·Nature Reviews. Urology·Erika J Espinosa-OrtizRobin Gerlach
Nov 8, 2020·Nature Reviews. Urology·Ashley AlfordJody Lulich
Jul 3, 2021·Journal of Clinical Medicine·Christophe Almeras On Behalf Of The Lithiasis Committee Of The French Urological Association