Endoscopic application of EGF-chitosan hydrogel for precipitated healing of GI peptic ulcers and mucosectomy-induced ulcers

Journal of Materials Science. Materials in Medicine
Jin Hee MaengSu-Geun Yang

Abstract

The gastrointestinal (GI) endoscopy has become a standard diagnostic tool for GI ulcers and cancer. In this study we studied endoscopic application of epidermal growth factor-containing chitosan hydrogel (EGF-CS gel) for treatment of GI ulcer. We hypothesized that directional ulcer-coating using EGF-CS gel via endoscope would precipitate ulcer-healing. EGF-CS gel was directly introduced to the ulcer-region after ulceration in acetic acid-induced gastric ulcer (AAU) and mucosal resection-induced gastric ulcer (MRU) rabbit and pig models. The ulcer dimensions and mucosal thicknesses were estimated and compared with those in the control group. Healing efficacy was more closely evaluated by microscopic observation of the ulcer after histological assays. In the AAU model, the normalized ulcer size of the gel-treated group was 2.3 times smaller than that in the non-treated control group on day 3 after ulceration (P < 0.01). In the MRU model, the normalized ulcer size of the gel-treated group was 5.4 times smaller compared to that in the non-treated control group on day 1 after ulceration (P < 0.05). Histological analysis supported the ability of EGF-CS gel to heal ulcers. The present study suggests that EGF-CS gel is a promising cand...Continue Reading

References

Oct 1, 1990·Antimicrobial Agents and Chemotherapy·R MuzzarelliP E Varaldo
Dec 1, 1988·Annals of Surgery·G L BrownG S Schultz
Dec 1, 1994·Biomaterials·G PelusoG Balsamo
May 1, 1994·The Journal of Pharmacy and Pharmacology·N CelebiM Koz
Nov 26, 1999·Journal of Biomedical Materials Research·K OnoM Ishihara
Oct 5, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Nevin CelebiCandan Ozogul
May 15, 2004·International Journal of Radiation Oncology, Biology, Physics·Roy S Herbst
Sep 24, 2004·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Takuya HayashiHisao Tajiri
Mar 11, 2006·Burns : Journal of the International Society for Burn Injuries·Ceren AlemdaroğluDeniz Erdoğan
Jul 20, 2006·The American Journal of Gastroenterology·Nicholas J ShaheenRobert S Sandler
Mar 6, 2007·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Takuji Gotoda
Jun 12, 2010·Journal of Biomedical Materials Research. Part a·Fiona RaskMilica Radisic
Jul 10, 2010·Annals of Biomedical Engineering·H HattoriM Ishihara
Sep 16, 2011·Current Gastroenterology Reports·Ingrid Lisanne Holster, Ernst Johan Kuipers
Mar 13, 2012·Journal of Tissue Engineering and Regenerative Medicine·Yoshifumi TsudaKoichi Nemoto

❮ Previous
Next ❯

Citations

Dec 1, 2014·Medicina clínica·Jordi Esquirol Caussa, Elisabeth Herrero Vila
Mar 16, 2017·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Vicente Lorenzo-ZúñigaRamón Bartolí
Nov 22, 2016·Advances in Wound Care·Kaushik MukherjeeAdrian Barbul
Jun 24, 2017·World Journal of Gastroenterology : WJG·Ignacio BonVicente Lorenzo-Zúñiga
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Karuppusamy ShanmugapriyaHyun Wook Kang
Jun 13, 2021·Journal of Materials Science. Materials in Medicine·Yi DingBochu Wang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.