Endoscopic characteristics and levodopa responsiveness of swallowing function in progressive supranuclear palsy

Movement Disorders : Official Journal of the Movement Disorder Society
Tobias WarneckeRainer Dziewas

Abstract

Dysphagia is a frequent and early symptom in progressive supranuclear palsy (PSP) predisposing patients to aspiration pneumonia. Fiberoptic endoscopic evaluation of swallowing (FEES) has emerged as a valuable apparative tool for objective evaluation of neurogenic dysphagia. This is the first study using FEES to investigate the nature of swallowing impairment in PSP. Eighteen consecutive PSP patients (mean age 69.7 +/- 9.0 years) were included. The salient findings of FEES in PSP patients were compared with those of 15 patients with Parkinson's disease (PD). In 7 PSP patients, a standardized FEES protocol was performed to explore levodopa (L-dopa) responsiveness of dysphagia. Most frequent abnormalities detected by FEES were bolus leakage, delayed swallowing reflex, and residues in valleculae and piriformes. Aspiration events with at least one food consistency occurred in nearly 30% of PSP patients. Significant pharyngeal saliva pooling was observed in 4 PSP patients. We found no difference of salient endoscopic findings between PSP and PD patients. Endoscopic dysphagia severity in PSP correlated positively with disease duration, clinical disability, and cognitive impairment. No correlation was found with dysarthria severity. In...Continue Reading

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Citations

Jun 8, 2011·Journal of Neurology·Sonja SuntrupRainer Dziewas
Nov 23, 2015·Dysphagia·Inga Suttrup, Tobias Warnecke
Apr 5, 2011·Parkinsonism & Related Disorders·Meng HanMitsuru Mori
Dec 3, 2015·Nature Reviews. Gastroenterology & Hepatology·Nathalie Rommel, Shaheen Hamdy
Feb 16, 2013·Brain : a Journal of Neurology·Sonja SuntrupTobias Warnecke
Jan 15, 2014·Journal of Neurology·Sara VaraneseMarco Onofrj
Jul 7, 2014·Parkinsonism & Related Disorders·Tobias WarneckeRainer Dziewas
Aug 2, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·I SuttrupT Warnecke
Apr 19, 2019·Internal Medicine·George Umemoto, Hirokazu Furuya
Aug 6, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Bendix LabeitRainer Dziewas
Aug 18, 2016·JBI Database of Systematic Reviews and Implementation Reports·Erica TilleyMicah D J Peters
Nov 5, 2019·Dysphagia·Heather M ClarkKeith A Josephs
Aug 6, 2017·Dysphagia·R DziewasUNKNOWN European Society for Swallowing Disorders
Aug 9, 2020·Frontiers in Neurology·Huiyan YuTao Xie
Oct 27, 2018·Movement Disorders Clinical Practice·Inga ClausTobias Warnecke
May 2, 2019·Frontiers in Neurology·Jens Burchard SchröderTobias Warnecke
Jun 18, 2020·Annals of Clinical and Translational Neurology·Sriramya LapaTobias Warnecke
Aug 11, 2020·Journal of Parkinson's Disease·Inga ClausTobias Warnecke
Nov 10, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Arun BalajiDevendra Chaukar
Apr 26, 2019·Neurological Research and Practice·Rainer DziewasTobias Warnecke
May 18, 2020·Parkinsonism & Related Disorders·Bendix LabeitTobias Warnecke
Mar 3, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Inga ClausTobias Warnecke
Apr 26, 2021·Brazilian Journal of Otorhinolaryngology·Aline PrikladnickiMaria Cristina Cardoso
Jun 27, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·James C BordersMichelle S Troche
Aug 25, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Heather M ClarkJennifer L Whitwell
Nov 14, 2018·Dementia and Geriatric Cognitive Disorders·Courtney LewisAdam P Vogel
Nov 14, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Annemarie VogelTobias Warnecke

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