Endoscopic diagnosis of cytomegalovirus infection of upper gastrointestinal tract in solid organ transplant recipients: Hungarian single-center experience

Clinical Transplantation
Antal PéterIlona Kovalszky

Abstract

Cytomegalovirus (CMV) is considered to be the major cause of upper gastrointestinal (GI) symptoms in organ transplant recipients. In the diagnosis of GI CMV infection the detection of the virus in the mucosa is essential. The aim of the study was to evaluate the significance of CMV, detected in biopsy specimens from stomach and duodenum of solid organ transplant recipients. Data of 227 elective upper endoscopies on symptomatic organ transplant recipients were evaluated for clinical symptoms, endoscopic changes and conventional histologic alterations of mucosal biopsy samples. Qualitative PCR was performed for detection of the presence of CMV-DNA in each biopsy materials. CMV-DNA was detected in biopsy samples of 91 patients (40.1%) while only in 20 cases (8.8%) the signs of CMV infections were found by conventional histology (p < 0.00001). No considerable differences could be observed in symptomatic, histologic alterations between CMV-PCR positive and negative groups. There were no endoscopic changes in 25.3% of CMV-PCR positive and 5.1% of negative patients. Qualitative PCR is an accurate method for the detection of CMV in the mucosa of the GI tract. Further investigations are needed for determination of the exact pathological...Continue Reading

References

Jun 1, 1992·Journal of Clinical Gastroenterology·C M Wilcox, D A Schwartz
May 1, 1991·Journal of Gastroenterology and Hepatology·A B Price
May 1, 1991·Journal of Gastroenterology and Hepatology·G N Tytgat
Feb 1, 1995·Surgical Endoscopy·S M GrahamA L Imbembo
Oct 1, 1994·Journal of Clinical Gastroenterology·R N MurrayE M Martinez
Nov 1, 1993·Annals of Internal Medicine·R W Goodgame
Oct 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·F S Buckner, C Pomeroy
Jan 1, 1993·The Annals of Thoracic Surgery·F A ArabiaJ G Copeland
Jul 17, 1998·Transplant International : Official Journal of the European Society for Organ Transplantation·L HalmeI Lautenschlager
Jul 13, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·B KaplanS Mulgaonkar
Dec 26, 2001·Journal of the American Society of Nephrology : JASN·J Harold Helderman, Simin Goral
Jun 18, 2003·Transplantation·Leena HalmeIrmeli Lautenschlager

❮ Previous
Next ❯

Citations

Jul 17, 2008·Current Gastroenterology Reports·Allison L Baroco, Edward C Oldfield
Aug 24, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Basol CanbakanBülent Erbay
Aug 14, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Marko LempinenIrmeli Lautenschlager
Jul 7, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gabor TelkesArgiris Asderakis
Jun 29, 2012·Case Reports in Gastroenterology·Chikara EbisutaniYoshikazu Kinoshita
Dec 4, 2008·Digestive Diseases and Sciences·Marcos Carvalho BorgesBenedito Antônio Lopes Fonseca
Jul 23, 2013·Gastrointestinal Endoscopy·Ravi N SharafBrooks D Cash
Sep 15, 2009·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Tina GanzenmuellerAlbert Heim
May 25, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Claudio Ponticelli, Patrizia Passerini
Apr 10, 2008·Transplant Infectious Disease : an Official Journal of the Transplantation Society·L LladóA Rafecas
Mar 7, 2008·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Leena HalmeIrmeli Lautenschlager
Jan 8, 2014·Journal for Specialists in Pediatric Nursing : JSPN·Cynthia BodeurKelly Ellington
Feb 27, 2015·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·H-W WangK-H Chen
Dec 18, 2008·Orvosi hetilap·Antal PéterJeno Járay
Mar 12, 2015·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Muhammed IshaqueMuhammed Mubarak
Sep 17, 2008·European Journal of Gastroenterology & Hepatology·Gábor TelkesZsolt Tulassay
Aug 22, 2009·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Eui Tae HwangSuck Chei Choi
Dec 2, 2005·Current Opinion in Gastroenterology·Kerri Thom, Graeme Forrest
Sep 1, 2015·GE Portuguese Journal of Gastroenterology·Armando PeixotoGuilherme Macedo
Dec 19, 2020·Open Medicine·Armando CalogeroMichele Santangelo
Sep 14, 2010·Transplantation Proceedings·G A Talmon

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.

© 2021 Meta ULC. All rights reserved