Endoscopic Endonasal Reconstruction of Anterior Skull Base Defects: What Factors Really Affect the Outcomes?

World Neurosurgery
M Turri-ZanoniPaolo Castelnuovo

Abstract

Endoscopic endonasal surgery has evolved in recent decades, requiring comparable advances in reconstructive techniques. This study aimed to retrospectively review outcomes of endoscopic anterior skull base reconstruction and to analyze factors associated with failures. Data from patients who underwent endoscopic endonasal anterior skull base reconstruction in a single institution between 1998 and 2017 were collected. Patients were stratified according to selected risk factors: sex; age; previous surgery; disease treated (cerebrospinal fluid leaks, benign tumors, malignant tumors); single or multiple defects; defect dimension (<1 cm2, 1-2 cm2, 2-6 cm2, >6 cm2) and site (olfactory cleft, ethmoidal roof, planum sphenoidalis, posterior wall of frontal sinus); reconstruction technique (overlay graft, multilayer grafts, pedicled flap) and materials used; postoperative radiotherapy; and year of surgery. Statistical significance was assessed using Fisher exact test. Univariate logistic regression was implemented to analyze the association between risk factors and failures. Inclusion criteria were met by 513 cases with median follow-up of 96 months (range, 12-257 months). Success rate for initial repair was 95% (487/513), with 100% succ...Continue Reading

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Citations

Apr 28, 2020·Laryngoscope Investigative Otolaryngology·Nyall R LondonPatrick C Walz
Jun 20, 2020·The Laryngoscope·Jacopo ZocchiPaolo Castelnuovo
Aug 29, 2019·Current Opinion in Otolaryngology & Head and Neck Surgery·Liliana EinElizabeth A Nicolli
May 19, 2020·Current Otorhinolaryngology Reports·Adnan S HussainiTimothy R DeKlotz
Mar 27, 2021·British Journal of Neurosurgery·Karan JollyShahzada Khuram Ahmed
Jan 26, 2021·Journal of Neurosurgical Sciences·Erion J DE AndradePablo F Recinos
Jun 3, 2021·American Journal of Rhinology & Allergy·Karan JollyShahzada K Ahmed
Nov 18, 2020·The Journal of Craniofacial Surgery·Ismail AytaçLütfi Semih Mumbuç
Nov 18, 2021·World Neurosurgery·Mario Turri-ZanoniPaolo Castelnuovo
Nov 16, 2019·European Annals of Otorhinolaryngology, Head and Neck Diseases·E ChabrillacS Vergez

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