Endoscopic endonasal transsphenoidal surgery for invasive pituitary adenoma

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Xiang ZhangShao-jun Song

Abstract

Invasive pituitary adenomas (IPA) involving the skull base extend from the sella region, and invade surrounding structures. In the present study, we reviewed the therapeutic efficacy in a group of patients with IPA treated with endoscopic endonasal transsphenoidal surgery. Data from 78 IPA patients at our hospital were retrospectively reviewed. The diagnostic modalities, surgical techniques, and outcomes were reviewed. Diagnosis was confirmed by endocrinological profile and CT or MRI in all patients. Surgery was performed via an endoscopic endonasal transsphenoidal approach. Thirty-five patients (44.9%) had hormonally active tumors, and 43 (55.1%) had nonfunctioning tumors. Complete removal of the tumor was achieved in 62 patients (79.5%) and subtotal removal in 12 (15.4%); partial removal was achieved in the remaining four patients (5.1%) who had fibrous or dumbbell-shaped adenomas. The mean follow-up was 43.2 months in 65 patients and the clinical symptoms in all patients improved to varying degrees. In 52 patients, the tumors completely disappeared on follow-up imaging. Visual symptoms improved in 96.4% of the patients who had presented with visual impairment. These surgical results show that endoscopic endonasal transspheno...Continue Reading

References

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Citations

Nov 9, 2010·Journal of Neurosurgery·Salvatore Di MaioPaolo Cappabianca
Jun 4, 2013·Journal of Neurosurgery·Kunal S PatelTheodore H Schwartz
Sep 28, 2010·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Chunlin WangXuehua Ding
May 11, 2012·ANZ Journal of Surgery·Joseph Y M YangAgadha Wickremesekera
Dec 18, 2015·Surgical Neurology International·José Alberto LandeiroFelippe Antunes
Dec 18, 2012·Journal of Neurology, Neurosurgery, and Psychiatry·Mario AmmiratiIvan Ciric
Jun 16, 2016·Frontiers in Endocrinology·Xianquan ZhanTingting Cheng
Aug 3, 2016·The Journal of Craniofacial Surgery·Seda UygunMustafa Berker

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