Endoscopic excision and repair of simulated bilateral cleft lips in fetal lambs

Plastic and Reconstructive Surgery
K C ObergR A Hardesty

Abstract

The use of nonpenetrating clips to accomplish wound closure as an alternative to suture in the repair of simulated cleft lips in partially exteriorized fetuses has been described previously. In this study, the fetus is approached endoscopically, and clipped (n = 8) and sutured (n = 4) intrauterine endoscopic repairs in six lambs (90- to 95-day gestation) are compared. Also used was a newly developed harmonic scalpel to create the defects in the fluid environment. Clipped repairs were nearly 10 times faster than sutured repairs (2.7 +/- 0.5 minutes compared with 24 +/- 4 minutes, respectively). Furthermore, suture incited foreign body inflammation, recruited monocytic inflammatory cells, and exhibited notable scarring. The comparison between clipped and sutured repairs extends the previous observations to the realm of endoscopy and reinforces the previous conclusions of this group that the nonpenetrating clip is more rapid and incites less inflammation than suture in fetal wound approximation and repair.

References

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Citations

Apr 16, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Enrico DanzerCraig T Albanese
Jan 29, 2011·Head & Face Medicine·Wolfgang EichhornMax Heiland
Aug 22, 2001·British Journal of Plastic Surgery·E ErelV Ramakrishnan
Jul 5, 2005·British Journal of Plastic Surgery·N A PapadopulosE Biemer
Jul 21, 2004·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Nikolaos A PapadopulosEdgar Biemer
Jun 23, 2011·Critical Care : the Official Journal of the Critical Care Forum·I-Chuan ChenCheng-Ting Hsiao
Mar 19, 2005·Burns : Journal of the International Society for Burn Injuries·Frederick W EndorfRichard L Gamelli
Jun 25, 2003·Journal of Dental Research·R HosokawaM Ohishi
Sep 28, 1999·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·B J Mehrara, M T Longaker
Feb 5, 2004·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·G Kratz, F Huss
Dec 2, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Piotr Wójcicki, Piotr H Drozdowski

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