Endoscopic Management of Infected Necrotizing Pancreatitis: an Evidence-Based Approach

Current Treatment Options in Gastroenterology
Lotte BoxhoornDutch Pancreatitis Study Group

Abstract

Endoscopic management of infected necrotizing pancreatitis has evolved rapidly over the past years and there have been interesting innovations in this field. This review provides an update on the most recently published literature regarding endoscopic management of infected necrotizing pancreatitis. A recent randomized trial demonstrated no difference in mortality and major morbidity between endoscopic and surgical step-up treatment of infected necrotizing pancreatitis. However, endoscopic therapy resulted in shorter hospital stay and less pancreatic fistulas. Various innovations have been investigated with the aim to further optimize endoscopic therapy, in particular lumen-apposing metal stents. While major stent-related complications were also reported, findings from recent studies indicated that their use was associated with higher resolution rates of walled-off necrosis compared to double-pigtail stents. Other innovations, such as the multiple gateway technique and dual-modality mode, can be considered for treatment of particular cases. Furthermore, research suggests that irrigation of walled-off necrosis can be performed by using a nasocystic tube and discontinuation of proton-pump inhibitors may be considered. Endoscopic ...Continue Reading

References

Sep 1, 1996·Gastroenterology·T H BaronR J Stanley
Feb 28, 2004·Gastroenterology·Marianna ArvanitakisCelso Matos
Oct 13, 2006·The American Journal of Gastroenterology·Peter A BanksUNKNOWN Practice Parameters Committee of the American College of Gastroenterology
Dec 7, 2007·Gastrointestinal Endoscopy·Christopher LawrenceBecky Benz
Jul 28, 2009·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·C BeattieD Burke
Oct 30, 2009·Gastrointestinal Endoscopy·Andrew RossRichard Kozarek
Apr 23, 2010·The New England Journal of Medicine·Hjalmar C van SantvoortUNKNOWN Dutch Pancreatitis Study Group
Sep 28, 2010·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Michael GluckRichard A Kozarek
Jul 12, 2011·Gastroenterology·Hjalmar C van SantvoortUNKNOWN Dutch Pancreatitis Study Group
Nov 30, 2011·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Michael GluckRichard A Kozarek
Mar 15, 2012·JAMA : the Journal of the American Medical Association·Olaf J BakkerUNKNOWN Dutch Pancreatitis Study Group
May 9, 2012·Journal of Clinical Gastroenterology·Lucas M DrakeChristopher Lawrence
Aug 14, 2012·Gastroenterology·Anne F PeeryNicholas J Shaheen
Oct 27, 2012·Gut·Peter A BanksUNKNOWN Acute Pancreatitis Classification Working Group
Jun 12, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Christopher Huang, Justin Pik
Jul 9, 2013·Journal of Gastroenterology and Hepatology·Ji Young BangShyam Varadarajulu
Sep 27, 2013·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·UNKNOWN Working Group IAP/APA Acute Pancreatitis Guidelines
Nov 28, 2013·Digestive Diseases and Sciences·Ali A SiddiquiGeorgios I Papachristou
Dec 7, 2013·British Journal of Neurosurgery·Prasanna S PatankarKishor A Choudhari
Mar 10, 2016·Nature Reviews. Gastroenterology & Hepatology·Janneke van GrinsvenUNKNOWN Dutch Pancreatitis Study Group
Apr 30, 2016·The American Journal of Gastroenterology·Ji Young Bang, Shyam Varadarajulu
Jul 19, 2016·Acta chirurgica Belgica·Yi YangDavid Penn
Jul 28, 2016·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Amol BapayeRavindra Gaadhe
Aug 20, 2016·Endoscopy International Open·Ji Young BangShyam Varadarajulu
Jan 13, 2017·Surgical Endoscopy·Florian KuehnErnst Klar

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Citations

Nov 17, 2019·Digestive Diseases and Sciences·M MinghettiV Tonini
Jun 28, 2019·Trauma Surgery & Acute Care Open·Melanie Kay Sion, Kimberly A Davis
Jan 21, 2021·The Korean Journal of Internal Medicine·Jeffrey James Easler
Feb 11, 2021·GE Portuguese Journal of Gastroenterology·Flávio PereiraMiguel Bispo

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