Endoscopic molecular imaging: status and future perspective

Clinical Endoscopy
Naoki MugurumaTetsuji Takayama

Abstract

During the last decade, researchers have made great progress in the development of new image processing technologies for gastrointestinal endoscopy. However, diagnosis using conventional endoscopy with white light optical imaging is essentially limited, and ultimately, we still rely on the histopathological diagnosis from biopsy specimens. Molecular imaging represents the most novel imaging methods in medicine, and the future of endoscopic diagnosis is likely to be impacted by a combination of biomarkers and technology. Endoscopic molecular imaging can be defined as the visualization of molecular characteristics with endoscopy. These innovations will allow us not only to locate a tumor or dysplastic lesion but also to visualize its molecular characteristics and the activity of specific molecules and biological processes that affect tumor behavior and/or its response to therapy. In the near future, these promising technologies will play a central role in endoluminal oncology.

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Citations

Nov 4, 2016·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Steven SensarnChristopher H Contag
May 31, 2018·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Shakil AhmedHelmut Neumann
Sep 10, 2014·Current Opinion in Gastroenterology·Raja Atreya, Markus F Neurath
May 1, 2020·Clinical and Translational Gastroenterology·Ben GloverNisha Patel
Aug 21, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Piper A RawdingSeungpyo Hong

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Methods Mentioned

BETA
biopsy
imaging techniques
biopsies
phage display
fluorescence microscopy

Software Mentioned

EMMI
DiMI
SOCRATES

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