Abstract
Endoscopic mucosal resection (EMR) of early gastric and esophageal tumors is effective and avoids the morbidity and mortality of surgery. We report the long-term results of a consecutive series of 93 endoscopic resections, during a 7-year period, in a U.K. population. Eighty-eight patients with 93 lesions were included. EMR was performed for 64 and 29 malignant and benign lesions, respectively. Patients with malignant disease were subgrouped into "high risk" or "low risk" for recurrence. Of the 35 lesions in the low-risk group, local control was achieved in 31; 29 after 1 EMR session. Two had residual invasive carcinoma, one had treatment ceased due to pancreatic cancer, and one patient did not attend follow-up. Of the 29 lesions in the high-risk group, local control was achieved in 15; 13 after 1 EMR session. Median follow-up was 53 months. Cancer specific survival for the 45 invasive cancers (T1m and T1sm) was 93%; three patients died from their disease. This study has shown for the first time in a U.K. population that EMR is effective in controlling disease in patients with local high grade dysplasia (HGD) and early invasive carcinoma, with no mortality and low morbidity.
References
Aug 1, 1976·Gastrointestinal Endoscopy·T R MartinJ A Vennes
Mar 1, 1994·Gastrointestinal Endoscopy·D M ChavesS Ishioka
Jan 1, 1993·Gastrointestinal Endoscopy·H InoueM Endo
Jul 1, 1996·Gastrointestinal Endoscopy·D E FleischerS Prifti
Jan 1, 1997·Gut·K TakeshitaM Endo
Jun 1, 1997·Endoscopy·N SoehendraG Gurakuqi
Dec 31, 1998·The Journal of Thoracic and Cardiovascular Surgery·J J NigroC G Bremner
Mar 29, 2000·Gastroenterology·C EllM Stolte
Nov 23, 2000·Annals of Surgery·H J SteinJ R Siewert
Jan 13, 2001·Gut·H OnoS Yoshida
Feb 28, 2002·Gastrointestinal Endoscopy·Nuzhat A AhmadGregory G Ginsberg
Feb 26, 2003·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Elaine E TsengRichard F Heitmiller
Jul 23, 2003·Gastrointestinal Endoscopy·Andrea MayChristian Ell
Jan 21, 2006·World Journal of Gastroenterology : WJG·Massimo ConioRosangela Filiberti
Dec 23, 2006·Gastrointestinal Endoscopy·Christian EllManfred Stolte
Feb 13, 2007·Surgical Endoscopy·C V LopesM Giovannini
May 15, 2007·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Marcello MiglioreFrancis C Wells
Aug 19, 2007·Endoscopy·A LarghiI Waxman
May 8, 2008·Gut·O PechC Ell
Citations
Dec 18, 2012·Irish Journal of Medical Science·N J O'FarrellD O'Toole
Nov 26, 2011·Gastrointestinal Endoscopy·Nirav ThosaniManoop S Bhutani
Nov 9, 2012·Journal of Digestive Diseases·Bashar J QumseyaTimothy Woodward
Nov 14, 2013·Cancer Science·Tomomitsu NasunoKatsuya Tsuchihara
Dec 5, 2014·Surgical Endoscopy·Justin T HuntingtonKyle A Perry
Nov 12, 2016·Surgical Endoscopy·Dongxian JiangYunshi Zhong
Jun 9, 2012·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·H P Priyantha SiriwardanaRafal Radzioch
May 19, 2017·Acta Oncologica·Ilkka VohlonenMatti Hakama
May 18, 2011·Minimally Invasive Therapy & Allied Technologies : MITAT : Official Journal of the Society for Minimally Invasive Therapy·Marc Oliver SchurrThomas Gottwald
Feb 9, 2021·Radiologic Clinics of North America·Sonia L Betancourt-CuellarWayne L Hofstetter