Endoscopic papillary balloon dilation causes transient pancreatobiliary and duodenobiliary reflux

Gastrointestinal Endoscopy
Masanori Sugiyama, Yutaka Atomi


Endoscopic papillary balloon dilation reduces sphincter function at least transiently or partially, which may allow pancreatobiliary and duodenobiliary reflux to occur. This study prospectively evaluated pancreatobiliary and duodenobiliary reflux after endoscopic papillary balloon dilation. In 12 patients with choledocholithiasis, ductal bile was sampled for amylase concentration and bacterial culture during ERCP, before and at 7 days to 5 years after endoscopic papillary balloon dilation. To provide comparative and control data, ductal bile was sampled in 12 patients with gallbladder cholesterol polyps and 6 with anomalous pancreaticobiliary junction who did not undergo endoscopic papillary balloon dilation. Amylase concentrations in ductal bile from patients with choledocholithiasis before endoscopic papillary balloon dilation were marginally significantly higher (before Bonferroni correction) compared with concentrations in bile from patients with gallbladder polyps. The concentration of amylase in bile was significantly increased at 7 days after endoscopic papillary balloon dilation compared with that before endoscopic papillary balloon dilation; the level was comparable with that of patients with an anomalous pancreaticobi...Continue Reading


Mar 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K ShimadaF Nakayama
Nov 1, 1993·Gastrointestinal Endoscopy·G R MayW Chong
Mar 23, 1999·The American Journal of Gastroenterology·M Sugiyama, Y Atomi
Apr 1, 2003·Gastrointestinal Endoscopy·Masanori SugiyamaYutaka Atomi

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