Endoscopic resection of superficial esophageal squamous-cell carcinomas: Western experience

The American Journal of Gastroenterology
Oliver PechChristian Ell

Abstract

Endoscopic resection of esophageal squamous-cell neoplasia with curative intent appears to be an alternative treatment to radical surgery when the malignant neoplasia is intraepithelial or limited to the mucosal layer, since the risk for lymph-node metastases is very low. In contrast to Japan, there has so far been only limited experience in Europe and the United States with endoscopic resection in such cases. In the present observational study, we report on the largest prospective series so far in Western countries of patients with early squamous-cell cancer or carcinoma in situ, who were treated using endoscopic resection therapy. Between December 1997 and November 2001, 115 patients with a suspicion of early squamous cancer were referred for local endoscopic therapy. A total of 39 patients (mean age 61.4 +/- 10.2 yr) with early esophageal carcinoma (n = 29) and carcinoma in situ (Cis) (n = 10) fulfilled the criteria for local endoscopic therapy and were treated using endoscopic resection. Ten patients had Cis (group A), 19 had mucosal cancer (group B), and 10 had submucosal cancer (group C). All patients in group C were inoperable or had refused surgery. A total of 94 resections were performed. Nine of the 10 patients in gro...Continue Reading

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Citations

Oct 17, 2008·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·W SchröderA H Hölscher
Oct 17, 2007·Gut·Oliver PechChristian Ell
Jul 31, 2008·World Journal of Gastroenterology : WJG·Mitsuhiro Fujishiro
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