PMID: 3749806Aug 1, 1986Paper

Endoscopic sclerotherapy of esophageal varices in an experimental animal model. A histomorphologic study

Scandinavian Journal of Gastroenterology
L S JensenT H Nielsen

Abstract

Endoscopic sclerotherapy with Aethoxysclerol 2% was carried out in rabbits with esophageal varices. Nineteen animals were injected paravenously, and 17 were injected intravenously. The animals were killed between 1 h and 4 weeks after injection for histologic examination of the esophagus. None of the animals showed an acute total occlusive thrombosis of the large vessels, whereas edema and later fibrosis compressed the varices in the paravenously injected animals. After 4 weeks an almost complete repair with patent varices was observed in the intravenously treated group, whereas the varices in the paravenously injected group either had shrunk totally or were surrounded by a dense envelope of connective tissue. The study suggests that paravenous treatment of esophageal varices provides a higher degree of efficacy.

References

Feb 1, 1978·Gastrointestinal Endoscopy·C SugawaA J Walt
Mar 1, 1986·Scandinavian Journal of Gastroenterology·L S JensenC Juhl
Jun 1, 1983·Annals of Internal Medicine·S J AyresG H Warren
Feb 1, 1984·Gastrointestinal Endoscopy·J L GrobeA Kovac
May 1, 1981·Gastrointestinal Endoscopy·M V SivakG Skipper
Jan 1, 1981·Langenbecks Archiv für Chirurgie·H HansenU Kunath
Feb 1, 1982·The British Journal of Surgery·M S BarsoumA S Ibrahim

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Citations

Jan 1, 1987·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·E MorsianiS Gullini
Aug 26, 2015·BMC Gastroenterology·Atsushi IgawaKazuaki Chayama
Sep 1, 1989·Scandinavian Journal of Gastroenterology·T DavionJ P Capron
May 1, 1995·Scandinavian Journal of Gastroenterology·R NishidaT Kita
Jan 1, 1996·Scandinavian Journal of Gastroenterology. Supplement·F Bendtsen, L S Jensen
Nov 1, 1994·Journal of Hepatology·A A Masclee, C B Lamers

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