Endoscopic studies of gastric and duodenal injury after the use of ibuprofen, aspirin, and other nonsteroidal anti-inflammatory agents

The American Journal of Medicine
F L Lanza


The toxic effects of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) were endoscopically evaluated in several studies conducted between 1975 and 1983 and involving 843 normal volunteers. Anti-inflammatory doses of acetylsalicylic acid (2,400 and 3,900 mg/day) consistently produced significantly more mucosal injury than did any of the newer NSAIDs. Buffering did not reduce the degree of damage. Little or no mucosal injury was seen with placebo, "pro drugs," enteric-coated aspirin, or 1,200 mg/day of ibuprofen (Motrin, Upjohn). However, varying degrees of generally dose-dependent mucosal injury were evident with larger doses of ibuprofen, naproxen, tolmetin sodium, and indomethacin. The amount of mucosal damage after 2,400 mg/day of ibuprofen did not increase when 4,800 mg daily was administered. Duodenal injury corresponded to gastric injury, but it was generally less severe. Short-term studies of one to three days indicated that ibuprofen produced little or no injury when given at a dose of 2,400 mg for one day or 1,600 mg/day for three days. No relation was noted between subjective symptoms and endoscopic findings.


Mar 1, 1973·The American Journal of Digestive Diseases·A R Cooke
Jan 1, 1983·Digestive Diseases and Sciences·D Y GrahamS M Dobbs
Apr 1, 1981·Journal of Clinical Pharmacology·F L LanzaB R Walker

❮ Previous
Next ❯


Apr 9, 2014·Digestive Diseases and Sciences·Mitsushige SugimotoTakahisa Furuta
Jun 27, 2000·Clinical Therapeutics·E V HershG L Ross
Jun 24, 1989·BMJ : British Medical Journal·C J SpakJ Ekstrand
Sep 1, 1993·Postgraduate Medical Journal·R OrenJ Zimmerman
Feb 24, 2009·Arthritis Research & Therapy·David T Felson
Mar 23, 2011·The Journal of Pharmacology and Experimental Therapeutics·Gang XieBasil Rigas
Aug 30, 2011·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Huma JawedShabana U Simjee
Apr 28, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Syed Uzair Ali ShahShabana Usman Simjee
Oct 16, 2015·Journal of Medicinal Food·Hong-Mei ZhengDon Haeng Lee
Jun 30, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·David Y Graham
Oct 28, 1999·Gastrointestinal Endoscopy·P D GreenbergD C Rockey
Jan 16, 2008·Alimentary Pharmacology & Therapeutics·S IraniR S Fisher
Mar 29, 2014·BioMed Research International·Koji Takeuchi, Kenji Nagahama
Aug 1, 1990·Journal of the American Geriatrics Society·N Agrawal
May 8, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Jerônimo Aparecido Ribeiro-JuniorPedro Luiz Rosalen
May 18, 2016·Journal of the American Pharmacists Association : JAPhA·Edward PaluchSarah Farnsworth
Mar 20, 2012·Biochemical and Biophysical Research Communications·Kaname OhyamaNaotaka Kuroda
Jan 8, 2005·Clinics in Sports Medicine·Robert T Gorsline, Christopher C Kaeding
Oct 28, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Jens Van Den AbeelePatrick Augustijns
Jul 22, 1998·The American Journal of Gastroenterology·F L LanzaE B Nelson
Jan 1, 1990·Journal of Clinical Pharmacology·H FriedmanG Royer
Jan 1, 1995·Arthritis and Rheumatism·D R LichtensteinM M Wolfe
Aug 1, 1996·Digestive Diseases and Sciences·G R LipscombW D Rees
Jan 5, 2002·Gastroenterology Clinics of North America·C W Houchen

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.