Abstract
After repair of oesophageal atresia (OA), the need for endoscopic follow-up (EFU) remains unclear. To end this, we assessed the trends of oesophageal mucosal changes in successive follow-up biopsies. EFU records of 264 patients including histological grades of oesophagitis (from 0 to III), gastric (GM) or intestinal (IM) metaplasia and dysplasia (mild to severe) at 1, 3, 5 10, 15, and >15 years after repair of OA were reviewed. Included were 209 patients with 616 biopsies. A total of 60 patients had undergone antireflux surgery and 24 had long-gap OA (LG). Median follow-up was 12 (range 1-17) years with 3 (1-6) endoscopies per patient. Highest grade of oesophagitis was Gr 0 (no oesophagitis) in 47%, Gr I in 37%, and Gr II or III in 16%. Metaplasia, GM (n = 31), IM (n = 4), occurred in 17% of patients and reached 15% prevalence by 15 years. Dysplasia and cancer were not found. From 1 to 15 years after repair grade of histological oesophagitis often fluctuated between Gr 0 and Gr I, but further progression was unlikely, hazard ratio = 0.2-3.4 (95% confidence interval 0.0-29), P = 0.06-0.87. LG and antireflux surgery predicted early detection of metaplasia (P < 0.001). Only 9% of patients with metaplasia and 32% with Gr II oesopha...Continue Reading
References
Oct 1, 1988·Gastroenterology·D J HetzelG G Gibson
Apr 30, 2003·Journal of Pediatric Surgery·Johannes SchalamonRisto J Rintala
Aug 6, 2005·Journal of Pediatric Surgery·Jacqueline A DeurlooDaniel C Aronson
Jun 5, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Andrew C F TaylorKeith Stokes
Jul 10, 2007·Biochimica Et Biophysica Acta·Jonathan M QuinlanDavid Tosh
Dec 12, 2007·Best Practice & Research. Clinical Gastroenterology·R Lambert, P Hainaut
Aug 8, 2008·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Marta C CohenMudher Al-Adnani
Mar 19, 2009·The American Journal of Gastroenterology·Weitian LiuRaj K Goyal
Jul 23, 2009·The American Journal of Gastroenterology·Robert H Riddell, Robert D Odze
May 21, 2010·Annals of Surgery·Saara J SistonenMikko P Pakarinen
May 21, 2010·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·Julie CastillouxChristophe Faure
Oct 19, 2010·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·S C BurjonrappaD St-Vil
Apr 22, 2011·Journal of Pediatric Gastroenterology and Nutrition·Eric Hassall
Jun 18, 2011·Journal of the National Cancer Institute·Shivaram BhatLiam J Murray
Oct 15, 2011·The New England Journal of Medicine·Frederik Hvid-JensenPeter Funch-Jensen
Apr 14, 2012·Journal of Pediatric Surgery·Chatura S JayasekeraAndrew C F Taylor
Nov 21, 2012·Gastrointestinal Endoscopy·John A EvansUNKNOWN Standards of Practice Committee of the American Society for Gastrointestinal Endoscopy
Feb 19, 2013·Journal of Pediatric Surgery·Antti I KoivusaloRisto J Rintala
May 18, 2013·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·S Maynard, M Bouin
May 18, 2013·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·A SchneiderF Gottrand
Jun 6, 2013·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·R J Rintala, M P Pakarinen
Dec 10, 2013·Journal of Pediatric Surgery·Rikke Neess PedersenSteffen Husby
Feb 11, 2014·Annals of Surgery·Santhoshi BandlaZhongren Zhou
Jul 1, 2014·British Journal of Biomedical Science·M BehanS Hayes
Jul 30, 2014·World Journal of Gastroenterology : WJG·Piers GatenbyMarc Winslet
Aug 19, 2014·World Journal of Gastrointestinal Pathophysiology·Piers Gatenby, Yuen Soon
Citations
Feb 2, 2017·Current Gastroenterology Reports·Arunjot SinghJulie Khlevner
Nov 28, 2017·Current Gastroenterology Reports·Hayat MousaChristophe Faure
Mar 29, 2019·Journal of Pediatric Gastroenterology and Nutrition·Jessica L YasudaMichael A Manfredi
Mar 2, 2017·Journal of Pediatric Gastroenterology and Nutrition·Helen HsiehChristophe Faure
May 31, 2017·Frontiers in Pediatrics·Risto J Rintala
Jun 23, 2018·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·A KoivusaloM Pakarinen
Apr 21, 2017·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Florian FriedmacherMichael E Höllwarth
Sep 13, 2020·The Journal of Pediatrics·Renato TambucciPaola De Angelis
Aug 10, 2021·BJS Open·L TullieN J Hall