Endoscopic survey of low-dose-aspirin-induced gastroduodenal mucosal injuries in patients with ischemic heart disease

Journal of Gastroenterology and Hepatology
Hiroaki NemaMasahiro Asaka

Abstract

Low-dose aspirin is effective for the prevention of cardiovascular and cerebrovascular events, but the frequency of gastrointestinal injuries among users of low-dose aspirin in Japan is currently unknown. In the present study endoscopic examination was performed to investigate the frequency of gastroduodenal injuries associated with low-dose aspirin in patients with ischemic heart disease (IHD). Screening upper endoscopic examinations were prospectively performed on 131 patients with IHD who were not receiving antiulcer treatment. Endoscopic findings such as ulcers and flat erosions were assessed as mucosal injuries. Mucosal injuries were found in 62 of 101 (61.4%) low-dose aspirin users and three of 30 (10%) nonaspirin users. There were significantly more mucosal injuries among low-dose aspirin users than among the non-users (P<0.0001). Gastroduodenal ulcers were found in 19 of 101 (18.8%) low-dose aspirin users compared with one of 30 (3.3%) nonaspirin users. The frequency of mucosal injuries was not associated with the duration of aspirin treatment. Endoscopy frequently reveals low-dose aspirin-induced gastroduodenal injuries in patients with IHD.

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Citations

Jul 14, 2010·Journal of Gastroenterology and Hepatology·Hiroaki Nema, Mototsugu Kato
Apr 5, 2013·World Journal of Gastroenterology : WJG·Junichi IwamotoYasushi Matsuzaki
Jan 27, 2012·Pharmacoepidemiology and Drug Safety·Jeffrey C MunsonSean Hennessy
Aug 8, 2014·Alimentary Pharmacology & Therapeutics·Ryuichi IwakiriKazuma Fujimoto
Sep 1, 2016·Gastroenterology Research and Practice·Anca NegovanClaudia Banescu
Mar 24, 2016·Journal of Cardiovascular Pharmacology·Jay L GoldsteinDavid J Whellan
Nov 14, 2017·Gastroenterology Research and Practice·Toshihiko TomitaHiroto Miwa

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