Endoscopic therapy for Barrett's oesophagus

Best Practice & Research. Clinical Gastroenterology
Christopher H Blevins, Prasad G Iyer

Abstract

Barrett's oesophagus (BO) is thought to progress through the development of dysplasia (low grade and high grade) to oesophageal adenocarcinoma, a lethal cancer with poor survival. The overall goal of endoscopic therapy of BO is to eliminate metaplastic and dysplastic epithelium, to prevent and/or reduce the risk of progression to OAC. Endoscopic therapy techniques can be divided into two broad complementary techniques: tissue acquiring (endoscopic mucosal resection and endoscopic submucosal dissection) and ablative. Endoscopic therapy has been established as safe and effective for the subjects with intra-mucosal cancer (IMC), high-grade dysplasia (HGD) and more recently in treating low-grade dysplasia (LGD). Challenges to endoscopic therapy are being recognized, such as incomplete response and recurrence. While eradication of intestinal metaplasia is the immediate goal of endoscopic therapy, surveillance must continue after complete elimination of intestinal metaplasia, to detect and treat recurrences.

References

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Citations

Feb 24, 2016·Gastrointestinal Endoscopy·Rajesh KrishnamoorthiPrasad G Iyer
Apr 5, 2017·The American Journal of Gastroenterology·Rajesh KrishnamoorthiPrasad G Iyer
May 10, 2016·World Journal of Gastrointestinal Pharmacology and Therapeutics·Irene MartinucciSantino Marchi
Oct 24, 2019·Mini Reviews in Medicinal Chemistry·Predrag DugalicEsma R Isenovic
Feb 11, 2020·Journal of Clinical Gastroenterology·Rajesh KrishnamoorthiPrasad G Iyer

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