Endoscopic ultrasound and computed tomography in restaging and predicting prognosis after neoadjuvant chemotherapy in patients with locally advanced gastric cancer

Cancer
Sook Ryun ParkIl Ju Choi

Abstract

The objective of the current study was to assess the staging accuracy and prognostic role of preoperative endoscopic ultrasound (EUS) and computed tomography (CT) in patients with locally advanced gastric cancer (LAGC) after neoadjuvant chemotherapy. Presurgical LAGC patients underwent EUS and CT before and after 3 cycles of neoadjuvant chemotherapy. Chemotherapy was comprised of docetaxel (at a dose of 36 mg/m(2)) and cisplatin (at a dose of 40 mg/m(2)) on Days 1 and 8 of a 3-week cycle. Forty patients were enrolled in the study. After chemotherapy, the accuracy of EUS and CT was found to be 47% and 57%, respectively for T classification (P = .22) and 39% and 37%, respectively for N classification (P > .99). The 3-year overall survival (OS) rate for patients downstaged with EUS for T and/or N classification was greater than that for nondownstaged patients (69% vs 41%; P = .05). The 2-year recurrence-free survival (RFS) rate was also better for the EUS-downstaged patients than for the nondownstaged patients (77% vs 47%; P = .04). On multivariate analysis, EUS downstaging was found to be correlated with OS (hazards ratio [HR] of 0.12; P = .04), and was correlated with RFS with borderline statistical significance (HR of 0.27; P =...Continue Reading

References

Jan 1, 1981·Cancer·A B MillerA Winkler
Jul 1, 1994·Gastrointestinal Endoscopy·M F CatalanoJ Van Dam
Jun 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D KelsenM Brennan
Apr 8, 1998·Journal of Computer Assisted Tomography·M TakaoS Okudaira
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J A AjaniD M Ota
Apr 17, 2002·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Jin-Pok KimHan-Kwang Yang
Aug 2, 2003·Lancet·Peter Hohenberger, Stephan Gretschel
Oct 2, 2003·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Katja OttUlrich Fink
Dec 23, 2003·The American Journal of Gastroenterology·Arvydas VanagunasSteven J Stryker
Jul 2, 2004·Gastrointestinal Endoscopy·Shouji ShimoyamaMichio Kaminishi
Jul 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J A AjaniL L Gunderson
Feb 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J A AjaniP W Pisters
Sep 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David D SmithRoderich E Schwarz
Oct 18, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Seok-Ki KimJae-Moon Bae
Oct 26, 2005·AJR. American Journal of Roentgenology·Kensaku ShimizuYasuhiko Kawakami
Feb 1, 2006·Surgical Endoscopy·I S GanpathiK-Y Ho
Jun 15, 2006·The American Journal of Gastroenterology·Afonso RibeiroBach Ardalan
Jul 11, 2006·The New England Journal of Medicine·David Cunningham MAGIC Trial Participants
Aug 26, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·D D'UgoR Ricci
May 22, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert Michael Kwee, Thomas Christian Kwee
Dec 1, 2002·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Hai Rim ShinJae Gahb Park

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Citations

Jan 8, 2009·Annals of Surgical Oncology·Sang Eok LeeYoung-Woo Kim
Apr 4, 2014·World Journal of Gastroenterology : WJG·Guo-Dong ShanGuo-Qiang Xu
Nov 8, 2011·Digestive Diseases and Sciences·Pietro FusaroliGiancarlo Caletti
Mar 30, 2011·Gastrointestinal Endoscopy·Simone MocellinDonato Nitti
Mar 9, 2010·Best Practice & Research. Clinical Gastroenterology·Henk Boot
Sep 12, 2009·Best Practice & Research. Clinical Gastroenterology·M Polkowski
Feb 21, 2009·Gastrointestinal Endoscopy·Thomas Rösch
Aug 29, 2009·Helicobacter·Jan BornscheinPeter Malfertheiner
Feb 27, 2010·Journal of Surgical Oncology·James J MezhirDaniel G Coit
Jul 22, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Zheng WangZhi-Xiang Zhou
Apr 9, 2015·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Young-Woo KimSook Ryun Park
Jun 12, 2012·The Journal of Surgical Research·Subhasis MisraLeonidas G Koniaris
Sep 21, 2016·BMJ Open Gastroenterology·Alex Yuang-Chi ChangKhong Hee Lim
Apr 29, 2015·The Cochrane Database of Systematic Reviews·Simone Mocellin, Sandro Pasquali
Feb 20, 2019·Journal of Minimal Access Surgery·Jie JiaoWenbin Yu
Mar 26, 2010·Scandinavian Journal of Gastroenterology·Weiguo ZhangShengbao Li
Jan 17, 2015·World Journal of Gastroenterology : WJG·Eun Hyo JinHyun Chae Jung
Aug 18, 2017·United European Gastroenterology Journal·Eduardo Redondo-CerezoJavier de Teresa
May 1, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·E C GertsenJ P Ruurda
Jul 15, 2021·World Journal of Surgical Oncology·Alina Desiree SandøErling Audun Bringeland
Oct 9, 2021·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·Giovanni CapovillaPeter Philipp Grimminger

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